(9Z,12Z)-十八碳-9,12-二烯醛 | 26537-70-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (9Z,12Z)-十八碳-9,12-二烯醛
• 英文名称: 9,12-Octadecadienal
• 英文别名: (9E,12E)-octadeca-9,12-dienal
• CAS: 26537-70-2
• 化学式: C₁₈H₃₂O
• 分子量: 264.4
• InChiKey: HXLZULGRVFOIDK-AVQMFFATSA-N

物化性质

• 沸点：
  365.4±21.0 °C(Predicted)
• 密度：
  0.852±0.06 g/cm3(Predicted)
• 保留指数：
  2150

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲基叔丁基醚 、 (9Z,12Z)-十八碳-9,12-二烯醛 生成 (Z,Z)-1-(1,1-dimethylethoxy)-10,13-nonadecadien-2-ol
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA
  申请人：Hadwiger Philipp

  公开号：US20120157509A1

  公开（公告）日：2012-06-21

  The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

  本发明涉及用于靶向递送RNA干扰（RNAi）多核苷酸至体内细胞的组合物。与单独的靶向配体相比，药代动力学调节剂改善了体内靶向。靶向配体-药代动力学调节剂靶向基团靶向的RNAi多核苷酸可以单独或与共靶向递送聚合物一起在体内给予。
• PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS
  申请人：PROVIVI, INC.

  公开号：US20170137365A1

  公开（公告）日：2017-05-18

  In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R 1 is independently selected from H, C 1-18 alkyl, and C 2-18 alkenyl; R 2b is C 1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

  在一个方面，该发明提供了一种合成脂肪烯衍生物的方法。该方法包括：a）在存在一种烯烃催化剂的条件下，将符合式I的烯烃与符合式IIb的交换反应伙伴接触，以形成符合式IIIb的交换产物；并b）将交换产物转化为脂肪烯衍生物。每个R1独立地选择自H、C1-18烷基和C2-18烯基；R2为C1-8烷基；下标y为0至17之间的整数；下标z为0至17之间的整数。在某些实施方式中，交换催化剂为钨催化剂或钼催化剂。在各种实施方式中，脂肪烯衍生物为信息素。还描述了信息素组合物及其使用方法。
• [EN] PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP<br/>[FR] DERIVES DE PYRROLOPYRIMIDINE ET DE PYRROLOPYRIDINE A SUBSTITUTION PAR UN GROUPE AMINO CYCLIQUE
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2004058767A1

  公开（公告）日：2004-07-15

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc.[SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I]:has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的一个目的是提供一种针对CRF受体的拮抗剂，该拮抗剂可作为治疗或预防剂用于CRF被认为参与的疾病，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、皮肤炎、精神分裂症等疾病。[解决方案] 一种用下式[I]表示的含有环状氨基团的吡咯吡嘧啶或吡咯吡啶衍生物具有高亲和力对CRF受体，并对CRF被认为参与的疾病有效。
• [EN] PROCESS FOR MAKING LINEAR LONG-CHAIN ALKANES FROM RENEWABLE FEEDSTOCKS USING CATALYSTS COMPRISING HETEROPOLYACIDS<br/>[FR] PROCÉDÉ DE FABRICATION D'ALCANES LINÉAIRES À CHAÎNE LONGUE À PARTIR DE MATIÈRES PREMIÈRES RENOUVELABLES EN UTILISANT DES CATALYSEURS COMPRENANT DES HÉTÉROPOLYACIDES
  申请人：DU PONT

  公开号：WO2014159490A1

  公开（公告）日：2014-10-02

  A hydrodeoxygenation process for producing a linear alkane from a feedstock comprising a saturated or unsaturated C10-18 oxygenate that comprises an ester group, carboxylic acid group, carbonyl group and/or alcohoi group is disclosed. The process comprises contacting the feedstock with a catalyst composition comprising a metal catalyst and a heteropolyacid or heteropo!yacid salt, at a temperature between about 240 °C to 280 °C and a hydrogen gas pressure of at least 300 psi. The metal catalyst comprises copper in certain embodiments. By contacting the feedstock with the catalyst composition under these temperature and pressure conditions, the C10-18 oxygenate is hydrodeoxygenated to a linear alkane that has the same carbon chain length as the C10-18 oxygenate.

  公开了一种水脱氧过程，用于从含有酯基、羧酸基、酮基和/或醇基的饱和或不饱和C10-18氧化物的原料生产直链烷烃。该过程包括将原料与包括金属催化剂和杂多酸或杂多酸盐的催化剂组合物接触，在温度约为240°C至280°C和至少300 psi的氢气压力下。在某些实施例中，金属催化剂包括铜。通过在这些温度和压力条件下将原料与催化剂组合物接触，C10-18氧化物被水脱氧成为具有与C10-18氧化物相同碳链长度的直链烷烃。
• AGRICULTURAL PHEROMONE COMPOSITIONS COMPRISING POSITIONAL ISOMERS
  申请人：PROVIVI, INC.

  公开号：US20170135343A1

  公开（公告）日：2017-05-18

  The present disclosure provides pheromone compositions. In some aspects, the compositions taught herein comprise a pheromone chemically corresponding to the pheromone naturally produced by a given insect, along with at least one positional isomer of said pheromone. In various aspects, pheromone compositions of the present disclosure are able to modulate the response of the insect based on the ratio of natural pheromone to its positional isomer.

  本公开提供信息素组合物。在某些方面，本文所教授的组合物包括一种与某种昆虫自然产生的信息素在化学上相对应的信息素，以及至少一种该信息素的位置异构体。在各个方面，本公开的信息素组合物能够通过自然信息素与其位置异构体的比例来调节昆虫的反应。

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