(9Z,12Z,15Z)-9,12,15-十八碳三烯酸异丙酯 | 83918-59-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (9Z,12Z,15Z)-9,12,15-十八碳三烯酸异丙酯
• 中文别名: 1-甲基乙基(9E,12E,15E)-十八碳-9,12,15-三烯酸酯
• 英文名称: Isopropyl (9Z,12Z,15Z)-9,12,15-octadecatrienoate
• 英文别名: propan-2-yl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• CAS: 83918-59-6
• 化学式: C₂₁H₃₆O₂
• 分子量: 320.5
• InChiKey: SQOVKJOWVZUDDC-AGRJPVHOSA-N

物化性质

• 保留指数：
  2200.3

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Composition for treating hair
  申请人：LION CORPORATION

  公开号：EP0435180A1

  公开（公告）日：1991-07-03

  A composition for hair comprises 2-amino-2-methyl-1, 3-propanediol salt, 2-amino-1-alkanol salt having 3 to 6 carbon atoms, monoalkylamine salt having 1 to 3 carbon atoms, lysine salt or histidine salt of adenosine 3', 5'-cyclic phosphoric acid or its derivative and an inert carrier. The composition may further comprise a nonionic surfactant having an HLB in the range of 3 to 19 or phosphoric ester-type anionic surfactant. The composition has effects of preventing graying of hair and restoring grayed hair to its natural color.

  用于头发的组合物包括 2-氨基-2-甲基-1，3-丙二醇盐、具有 3 至 6 个碳原子的 2-氨基-1-烷醇盐、具有 1 至 3 个碳原子的单烷基胺盐、3'，5'-环磷酸腺苷或其衍生物的赖氨酸盐或组氨酸盐以及惰性载体。该组合物还可进一步包含 HLB 在 3 到 19 之间的非离子表面活性剂或磷酸酯型阴离子表面活性剂。 该组合物具有防止头发变白和使变白的头发恢复自然颜色的功效。
• CHLOASMA AMELIORATION COMPOSITION AND DULLNESS AMELIORATION COMPOSITION
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1512405A1

  公开（公告）日：2005-03-09

  The present invention provides a composition that can effectively improve melasma and a composition that can effectively reduce skin dullness. The composition for improving melasma comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The composition for reducing skin dullness comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.

  本发明提供了一种可有效改善黄褐斑的组合物和一种可有效减轻皮肤暗沉的组合物。 用于改善黄褐斑的组合物包括一种嘌呤核酸相关物质和一种药学上或化妆品上可接受的载体，由于所含嘌呤核酸相关物质的作用，该组合物具有极佳的改善黄褐斑的效果。 减少皮肤暗沉的组合物包含一种嘌呤核酸相关物质和一种药学上或化妆品上可接受的载体，由于所含嘌呤核酸相关物质的作用，该组合物具有极佳的减少皮肤暗沉的效果。
• METHOD OF PRODUCING DRUG-CONTAINING WAX MATRIX PARTICLES, EXTRUDER TO BE USED IN THE METHOD AND SUSTAINED-RELEASE PREPARATION CONTAINING CILOSTAZOL
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1970040A1

  公开（公告）日：2008-09-17

  The present invention aims to provide a method for producing, by a simple method, drug-containing wax matrix granules, particularly drug-containing wax matrix granules having an average particle diameter of 1 mm or lower, while avoiding liquid blockage due to the recrystallization of a molten drug during the period from a melting step to a spray step. Drug-containing wax matrix granules having at least one wax and at least one drug are produced by the following steps (i) and (ii): (i) supplying the at least one drug and the at least one wax to an extruder in which the temperature of a barrel and the temperature of a die are adjusted to be higher than the melting point of the at least one wax; and (ii) while melting and kneading the at least one drug and the at least one wax in the extruder to give a molten kneaded drug and wax, spraying the molten kneaded drug and wax into an atmosphere having a temperature lower than the melting point of the wax from a spray nozzle directly mounted onto a die provided at a top end of the barrel of the extruder, thereby forming the mixture into granules.

  本发明旨在提供一种用简单方法生产含药蜡基质颗粒的方法，特别是平均颗粒直径为1毫米或更小的含药蜡基质颗粒，同时避免在从熔化步骤到喷雾步骤期间由于熔融药物的再结晶而造成的液体堵塞。 通过以下步骤(i)和(ii)生产具有至少一种蜡和至少一种药物的含药蜡基质颗粒：(i) 将至少一种药物和至少一种蜡提供给挤压机，在挤压机中，机筒的温度和模具的温度被调节到高于至少一种蜡的熔点；(ii) 在挤压机中熔化和揉捏至少一种药物和至少一种蜡以得到熔融的揉捏药物和蜡时，从直接安装在挤压机机筒上端模头的喷嘴向温度低于蜡熔点的大气中喷射熔融的揉捏药物和蜡，从而将混合物制成颗粒。
• Composition for improving melasma and composition for reducing skin dullness
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2517712A1

  公开（公告）日：2012-10-31

  The present invention provides a cosmetic composition that can effectively improve melasma and a cosmetic composition that can effectively reduce skin dullness. The cosmetic composition for improving melasma comprises a purine nucleic acid-related substance and a cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The cosmetic composition for reducing skin dullness comprises a purine nucleic acid-related substance and a cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.

  本发明提供了一种可有效改善黄褐斑的化妆品组合物和一种可有效减轻皮肤暗沉的化妆品组合物。 用于改善黄褐斑的化妆品组合物由一种嘌呤核酸相关物质和一种化妆品可接受载体组成，由于所含嘌呤核酸相关物质的作用，该组合物具有极佳的改善黄褐斑的效果。减少皮肤暗沉的化妆品组合物由嘌呤核酸相关物质和化妆品可接受载体组成，由于所含嘌呤核酸相关物质的作用，减少皮肤暗沉的效果极佳。
• Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2724704A1

  公开（公告）日：2014-04-30

  A sustained-release preparation is provided which contains granules comprising (A) cilostazol crystals; and (B) glycerol fatty acid ester and/or polyglycerol fatty acid ester. The average particle diameter of the granules ranges from 40 to 200 µm.

  本发明提供了一种缓释制剂，其中包含由以下成分组成的颗粒：(A) 西洛他唑晶体；(B) 甘油脂肪酸酯和/或聚甘油脂肪酸酯。颗粒的平均粒径为 40 至 200 微米。