(9ci)-1H-苯并咪唑-1-甲烷硫醇 | 105377-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: (9ci)-1H-苯并咪唑-1-甲烷硫醇
• 英文名称: (1H-Benzimidazol-1-yl)methanethiol
• 英文别名: benzimidazol-1-ylmethanethiol
• CAS: 105377-24-0
• 化学式: C₈H₈N₂S
• 分子量: 164.23
• InChiKey: JWIZNEGYFSSTLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  18.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Triazole Derivative and Use Thereof
  申请人：Kubo Keiji

  公开号：US20090105253A1

  公开（公告）日：2009-04-23

  The present invention relates to a thrombin receptor antagonist containing a compound represented by the formula (I) wherein R 1a , R 1b and R 2 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted alkoxy, R 3 is a group represented by the formula —NHCOR 4 , —NHSO 2 R 5 , —NHCON(R 6a )(R 6b ), —NHCOOR 7 or —CONHR 8 wherein R 4 , R 5 , R 6a , R 6b , R 7 and R 8 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like), ring A is monocyclic aromatic ring optionally further having substituent(s), R 1a and R 1b are optionally bonded to each other to form an optionally substituted nitrogen-containing non-aromatic heterocycle, or a salt thereof or a prodrug thereof. The thrombin receptor antagonist of the present invention has a thrombin receptor (particularly PAR-1) antagonistic action and is useful for the prophylaxis or treatment of PAR-1 mediated pathological condition or disease.

  本发明涉及一种含有式(I)所表示的化合物的凝血酶受体拮抗剂，其中R1a、R1b和R2分别是氢原子、可选取代的碳氢基团、可选取代的杂环基团或可选取代的烷氧基，R3是由式—NHCOR4、—NHSO2R5、—NHCON(R6a)(R6b)、—NHCOOR7或—CONHR8所表示的基团，其中R4、R5、R6a、R6b、R7和R8分别是氢原子、可选取代的碳氢基团、可选取代的杂环基团等，环A是单环芳香环，可选地进一步具有取代基，R1a和R1b可选择性地连接在一起形成可选取代的含氮非芳香杂环，或其盐或前药。本发明的凝血酶受体拮抗剂具有凝血酶受体（特别是PAR-1）拮抗作用，可用于预防或治疗PAR-1介导的病理状态或疾病。
• Cephalosporin derivatives, processes for their preparation and antibacterial agents
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：EP0241901A2

  公开（公告）日：1987-10-21

  l. A compound having the formula: wherein R is a straight chain or branched chain lower alkyl, cyclic lower alkyl, lower alkenyl (except for I-carboxy-l-vinyl), lower alkynyl, aralkyl, phenyl or 2-pyrrolidon-3-yl group which may be substituted, and Q is (wherein R' is a hydrogen atom or an acetyl group, R2 is a hydrogen atom, a carboxyl group or a carboxymethyl group, Y is a sulfur atom or an oxygen atom, Z is a sulfur atom, an oxygen atom or an imino group which may be substituted by a lower alkyl group); or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.

  l. 具有以下式子的化合物： 其中 R 是可被取代的直链或支链低级烷基、环状低级烷基、低级烯基（I-羧基-l-乙烯基除外）、低级炔基、芳基、苯基或 2-吡咯烷-3-基，Q 是（其中 R' 是氢原子或乙酰基，R2 是氢原子、羧基或羧甲基，Y 是硫原子或氧原子，Z 是硫原子、氧原子或可被低级烷基取代的亚氨基）；或其药学上可接受的盐、生理上可水解的酯或溶液。
• RUBBER COMPOSITION CONTAINING METAL SALT OF ETHYLENICALLY UNSATURATED CARBOXYLIC ACID
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0972797A1

  公开（公告）日：2000-01-19

  This invention provides a crosslinkable rubber composition comprising a nitrile-containing highly saturated copolymer rubber, a metal salt of an α,β-ethylenically unsaturated carboxylic acid, and an organic peroxide, wherein the nitrile-containing highly saturated copolymer rubber is characterized by having been treated by applying a high shearing force thereto in the presence of an antioxidant so as to reduce its Mooney viscosity by 15 points or greater, by having a Mooney viscosity of 5 to 135 and a molecular weight distribution (Mw/Mn) of 3.0 to 5.0, and by showing a Mooney viscosity increase of 10 points or less when it is allowed to stand at room temperature for 30 days after the reduction of its Mooney viscosity. Rubber materials (e.g., belts, rolls and hoses) obtained by crosslinking this composition have improved strength properties.

  本发明提供了一种可交联橡胶组合物，该组合物由含丁腈的高饱和共聚橡胶、α,β-乙烯基不饱和羧酸的金属盐和有机过氧化物组成、其中，含腈高饱和共聚橡胶的特征是，在有抗氧化剂存在的情况下，通过对其施加高剪切力进行处理，以降低其门尼罗粘度 15 点或更高，门尼罗粘度为 5 至 135，分子量分布（Mw/Mn）为 3.在降低门尼粘度后，在室温下放置 30 天，门尼粘度增加 10 点或更少。通过交联这种组合物获得的橡胶材料（如皮带、辊子和软管）具有更好的强度特性。
• MIXTURE COMPOSITION OF SYNTHETIC RESIN AND RUBBER
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0972798A1

  公开（公告）日：2000-01-19

  The present invention is directed to a polymer blend having improved properties comprising: (A) 90 to 10 % by weight of a thermoplastic or thermosetting resin; and (B) 10 to 90 % by weight of a shear-treated rubber obtained by subjecting a nitrile group-containing highly saturated copolymer rubber to a high-shear treatment in the presence of an anti-oxidant so as to lower the Mooney viscosity of the copolymer rubber by 15 units or more, said shear-treated rubber having a Mooney viscosity of 5 to 135, a molecular weight distribution (Mw/Mn) of 3.0 to 5.0 and a storage stability characterized by that the incremental increase in the Mooney viscosity of said shear-treated rubber during a 30 day storage under an ambient condition in air is not more than 10 units.

  本发明涉及一种具有改进性能的聚合物混合物，它包括(A) 90%至 10%（重量百分比）的热塑性或热固性树脂；以及 (B) 10%至 90%（重量百分比）的剪切处理过的橡胶，该橡胶是通过在抗氧化剂存在下对含有腈基的高饱和共聚橡胶进行高剪切处理，从而使共聚橡胶的门尼粘度降低 15 个单位或更多，所述剪切处理过的橡胶的门尼粘度为 5 至 135，分子量分布（Mw/Mn）为 3.经剪切处理的橡胶的门尼粘度为 5 至 135，分子量分布（Mw/Mn）为 3.0 至 5.0，贮存稳定性为在空气中环境条件下贮存 30 天期间，经剪切处理的橡胶的门尼粘度增量不超过 10 个单位。
• NITRILE RUBBER COMPOSITION, VULCANIZABLE NITRILE RUBBER COMPOSITION, AND VULCANIZATE
  申请人：Zeon Corporation

  公开号：EP1277796A1

  公开（公告）日：2003-01-22

  A vulcanizable nitrile rubber composition comprising 100 parts by weight of a nitrile rubber, 0.1 to 20 parts by weight of a metal silicate and 0.1 to 10 parts by weight of a vulcanizing agent. Vulcanization of this vulcanizable rubber composition gives a vulcanizate exhibiting enhanced heating aging resistance when it is kept in a hot air atmosphere, especially at a high temperature.

  一种可硫化丁腈橡胶组合物，包括 100 份（按重量计）丁腈橡胶、0.1 至 20 份（按重量计）金属硅酸盐和 0.1 至 10 份（按重量计）硫化剂。这种可硫化橡胶组合物经硫化后，在热空气环境中，特别是在高温下，硫化胶的耐加热老化性能增强。