2-Methyl-N,N-bis-[2-(2-methyl-acryloylamino)-ethyl]-acrylamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Methyl-N,N-bis-[2-(2-methyl-acryloylamino)-ethyl]-acrylamide
• 英文别名: 2-methyl-N-[2-[2-methylprop-2-enoyl-[2-(2-methylprop-2-enoylamino)ethyl]amino]ethyl]prop-2-enamide
• 化学式: C₁₆H₂₅N₃O₃
• 分子量: 307.393
• InChiKey: UJTYJYUYNSQQPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二乙烯三胺 、 甲基丙烯酰氯 以 二氯甲烷 为溶剂， 反应 24.0h， 以22%的产率得到2-Methyl-N,N-bis-[2-(2-methyl-acryloylamino)-ethyl]-acrylamide
  参考文献：
  名称：

  Synthesis, Characterization, and Modelling of Novel Multifunctional Acryloyl-Based Monomers: An Experimental and Computational Study

  摘要：

  我们合成了几种至少具有三个活性 N-丙烯酰双键的新型多功能单体，并对其进行了全面鉴定。量子化学计算和核磁共振（NMR）光谱被用来预测这些单体的结构不对称性：通过模拟单体（3）的构象和 NMR 光谱，可以解释观察到的 13C NMR 光谱，并比较几种计算化学位移方法的性能。

  DOI：

  10.1071/ch01082

文献信息

• SELF-ADHESIVE DENTAL COMPOSITE RESIN
  申请人：KURARAY NORITAKE DENTAL INC.

  公开号：US20200179237A1

  公开（公告）日：2020-06-11

  The present invention provides a self-adhesive dental composite resin maintaining mechanical strength, showing excellent storage stability, undergoing little change in transparency and properties of the paste during long-term storage, and having a small solidification risk during long-term storage. The present invention relates to a self-adhesive dental composite resin comprising: an acid group-containing (meth)acrylic polymerizable monomer (a); a polyfunctional (meth)acrylic polymerizable monomer (b) containing no acid group; a photopolymerization initiator (c); and a filler (d), wherein the filler (d) is treated with a surface treatment agent and has an average particle diameter of 0.01 to 50.0 μm, the surface treatment agent comprises a silane coupling agent (A) represented by the following general formula (1): CH 2 ═C(R 1 )—COO—(CH 2 ) p —Si—R 2 q R 3 (3-q) (1), and an organosilazane (B) represented by the following general formula (2): R 4 R 5 R 6 —Si—NH—Si—R 7 R 8 R 9 (2).

  本发明提供了一种保持机械强度的自粘合牙科复合树脂，表现出优异的储存稳定性，在长期储存过程中透明度和糊状物性质变化很小，并且在长期储存过程中固化风险很小。本发明涉及一种自粘合牙科复合树脂，包括：含酸基的（甲）丙烯酸聚合单体（a）；不含酸基的多官能（甲）丙烯酸聚合单体（b）；光聚合引发剂（c）；和填料（d），其中填料（d）经过表面处理剂处理，具有0.01到50.0μm的平均粒径，表面处理剂包括以下一般式（1）表示的硅烷偶联剂（A）：CH2═C(R1)—COO—( )p—Si—R2qR3(3-q)(1)，以及以下一般式（2）表示的有机硅氮烷（B）：R4R5R6—Si—NH—Si—R7R8R9(2)。
• Dental adhesive
  申请人：KURARAY NORITAKE DENTAL INC.

  公开号：US10456333B2

  公开（公告）日：2019-10-29

  Provided herein is a self-etching dental adhesive that exhibits excellent adhesiveness not only to dentin untreated by phosphoric acid etching, but to dentin treated by phosphoric acid etching. The present invention relates to a dental adhesive containing a (meth)acrylamide compound (a), an asymmetric acrylamide-methacrylic acid ester compound (b), and an acid group-containing (meth)acrylic polymerizable monomer (c). The (meth)acrylamide compound (a) is at least one selected from the group consisting of compounds represented by general formula (1), and compounds represented by general formula (2). The asymmetric acrylamide-methacrylic acid ester compound (b) is a compound represented by general formula (3). (In the formulae, the meanings of the symbols are omitted.)

  本发明提供了一种自酸蚀牙科粘合剂，它不仅对未经磷酸酸蚀处理的牙本质，而且对经磷酸酸蚀处理的牙本质都具有优异的粘合性。本发明涉及一种含有（甲基）丙烯酰胺化合物（a）、不对称丙烯酰胺-甲基丙烯酸酯化合物（b）和含酸基的（甲基）丙烯酸可聚合单体（c）的牙科粘合剂。(甲基)丙烯酰胺化合物(a)至少选自通式(1)所代表的化合物和通式(2)所代表的化合物组成的组。不对称丙烯酰胺-甲基丙烯酸酯化合物 (b) 是通式 (3) 所代表的化合物。 (式中符号含义省略）。
• Self-adhesive dental composite resin
  申请人：KURARAY NORITAKE DENTAL INC.

  公开号：US10987281B2

  公开（公告）日：2021-04-27

  The present invention provides a self-adhesive dental composite resin maintaining mechanical strength, showing excellent storage stability, undergoing little change in transparency and properties of the paste during long-term storage, and having a small solidification risk during long-term storage. The present invention relates to a self-adhesive dental composite resin comprising: an acid group-containing (meth)acrylic polymerizable monomer (a); a polyfunctional (meth)acrylic polymerizable monomer (b) containing no acid group; a photopolymerization initiator (c); and a filler (d), wherein the filler (d) is treated with a surface treatment agent and has an average particle diameter of 0.01 to 50.0 μm, the surface treatment agent comprises a silane coupling agent (A) represented by the following general formula (1): CH2═C(R1)—COO—(CH2)p—Si—R2qR3(3-q)  (1), and an organosilazane (B) represented by the following general formula (2): R4R5R6—Si—NH—Si—R7R8R9  (2).

  本发明提供了一种自粘性牙科复合树脂，它能保持机械强度，具有极佳的贮存稳定性，在长期贮存过程中浆料的透明度和性能变化很小，在长期贮存过程中固化风险很小。本发明涉及一种自粘性牙科复合树脂，包括：含酸性基团的（甲基）丙烯酸可聚合单体（a）；不含酸性基团的多功能（甲基）丙烯酸可聚合单体（b）；光聚合引发剂（c）；以及填料（d），其中填料（d）经表面处理剂处理，平均颗粒直径为 0.01 至 50.0 μm，表面处理剂包括硅烷偶联剂（A），由以下通式（1）表示： CH2═C(R1)-COO-( )p-Si-R2qR3(3-q) (1)，和 由下式通式（2）表示的有机硅氮烷（B）： R4R5R6-Si-NH-Si-R7R8R9 (2).
• PROCESS FOR THE FIXATION OF DYES CONTAINING AT LEAST ONE POLYMERISABLE DOUBLE BOND BY MEANS OF IONISING RADIATION
  申请人：CIBA-GEIGY AG

  公开号：EP0642609A1

  公开（公告）日：1995-03-15
• MULTI-PACK TYPE DENTAL CEMENT
  申请人：Kuraray Noritake Dental Inc.

  公开号：EP3530258B1

  公开（公告）日：2021-08-18