(E)-(2-(肉桂氧基)乙基)苯 | 122380-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (E)-(2-(肉桂氧基)乙基)苯
• 英文名称: (E)-(2-(cinnamyloxy)ethyl)benzene
• 英文别名: [(E)-3-(2-phenylethoxy)prop-1-enyl]benzene
• CAS: 122380-14-7
• 化学式: C₁₇H₁₈O
• 分子量: 238.329
• InChiKey: JUMBIPGHHPCYOQ-KPKJPENVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-苯基-1-丙炔 、 苯乙醇 在 四(三苯基膦)钯 、 苯甲酸 作用下， 以 1,4-二氧六环 为溶剂， 以89%的产率得到(E)-(2-(肉桂氧基)乙基)苯
  参考文献：
  名称：

  Palladium-catalyzed coupling of alkynes with alcohols and carboxylic acids

  摘要：

  The palladium-catalyzed coupling of alkynes with alcohols and carboxylic acids to give allylic ethers and esters has been achieved. With phenols, these conditions furnish the C-alkylation products. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01436-3

文献信息

• Step-economy etherification of acylated alcohols
  作者：Hua-Dong Xu、Ke Xu、Qing Zheng、Wei-Jie He、Mei-Hua Shen、Wen-Hao Hu

  DOI：10.1016/j.tetlet.2014.10.077

  日期：2014.12

  An efficient and convenient protocol has been developed for ether bond formation in mild conditions. A mixture of primary/secondary ester and allylic/benzylic halide in tetrahydrofuran was treated with KOtBu at room temperature to give ether in high yield. This step economic method enabled direct alkylation of the acyl group masked O-nucleophiles. Application of this method in carbohydrate synthesis

  已经开发出一种有效且方便的方案，用于在温和条件下形成醚键。在室温下用KO t Bu处理伯/仲酯和烯丙基/苄基卤化物在四氢呋喃中的混合物，以高收率得到醚。此步骤的经济方法使酰基掩蔽的O-亲核试剂能够直接烷基化。该方法在碳水化合物合成中的应用是可行的，并且可以实现化学选择性。
• [EN] FENDILINE DERIVATIVES AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS DE FENDILINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV TEXAS

  公开号：WO2014031755A1

  公开（公告）日：2014-02-27

  Disclosed herein are novel derivatives of fendiline, including compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives, for example, for the inhibition of K-Ras plasma membrane localization, and compositions thereof, including for the treatment of cancer, are also provided.

  本发明公开了芬地林的新的衍生物，包括具有以下通式的化合物：其中变量在本发明中定义。还提供了包含这些衍生物化合物的药物组合物、试剂盒和制品。本发明还提供了用于制造衍生物的方法和中间体，以及使用衍生物的方法，例如，用于抑制K-Ras质膜定位，以及用于治疗癌症的此类组合物。
• Reduction of Aldehyde with Tributyltin Hydride-HMPA Combined System
  作者：Ikuya Shibata、Tomoyuki Yoshida、Akio Baba、Haruo Matsuda

  DOI：10.1246/cl.1989.619

  日期：1989.4

  Bu3SnH–HMPA combined system is an efficient reagent for the reduction of aldehydes. The reaction proceeds in good yields, and chemoselective carbonyl reduction is achieved for the substrate which includes another reducible group. Moreover, the intermediate, tin alkoxide, undergoes further reaction such as the preparation of ethers and heterocyclic compounds in the one pot procedure.

  Bu3SnH–HMPA结合体系是一种高效的试剂，用于还原醛。反应产率良好，并且对包含其他可还原基团的底物实现了化学选择性的羰基还原。此外，中间体锡醇盐还可进一步反应，例如在一锅法中制备醚和杂环化合物。
• Gold(<scp>i</scp>)-catalysed direct allylic etherification of unactivated alcohols
  作者：Paul C. Young、Nina A. Schopf、Ai-Lan Lee

  DOI：10.1039/c2cc36760b

  日期：——

  Direct allylic etherification of unactivated alcohols occurs regio- and stereoselectively under mild, gold(I)-catalysed conditions.

  未活化的醇的直接烯丙基醚化在温和的金（I）催化条件下发生区域选择性和立体选择性。
• Etherification of alkoxydialkylsilanes with carbonyl compounds
  作者：Xinglong Jiang、Joginder S Bajwa、Joel Slade、Kapa Prasad、Oljan Repič、Thomas J Blacklock

  DOI：10.1016/s0040-4039(02)02253-0

  日期：2002.12

  A novel method for preparing ethers from alkoxydialkylsilanes and carbonyl compounds through reductive etheritication is described. The salient feature in this method is the utilization of internal hydrogen as the hydride source for reducing the oxonium intermediate generated by using the Cl(R)(2)SiBr[BiBr3/Cl(R)(2)SiH] catalytic system. (C) 2002 Published by Elsevier Science Ltd.