ethyl 3-(2,3-dihydro-1H-indol-5-yl)-5-methylhexanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 3-(2,3-dihydro-1H-indol-5-yl)-5-methylhexanoate
• 化学式: C₁₇H₂₅NO₂
• 分子量: 275.4
• InChiKey: XKFFFKXWYSOULH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] 2,3-DIHYDRO-1H-INDOLINYL-ALKANOIC ACIDS AS CELL ADHESION INHIBITORS<br/>[FR] ACIDES 2,3-DIHYDRO-1H-INDOLINYL-ALKANOÏQUES EN TANT QU'INHIBITEURS D'ADHÉSION CELLULAIRE
  申请人：AVENTIS PHARMA LTD

  公开号：WO2001064640A1

  公开（公告）日：2001-09-07

  The invention is directed to selected physiologically active 2,3-dihydro-1h-indolinyl-alkanoic acids including the corresponding N-oxides and prodrugs of such compounds; and pharmaceutically acceptable salts and solvates of such compounds and their corresponding N-oxides and prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (α4ß1). Thus, in one aspect, the present invention is directed to compounds of formula (III).