(E)-6-氨基-2-己烯酸盐酸盐 | 19991-88-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (E)-6-氨基-2-己烯酸盐酸盐
• 英文名称: (E)-6-amino-hex-2-enoic acid hydrochloride
• 英文别名: (E)-6-Amino-2-hexenoic Acid Hydrochloride；(E)-6-aminohex-2-enoic acid;hydrochloride
• CAS: 19991-88-9
• 化学式: C₆H₁₁NO₂*ClH
• 分子量: 165.62
• InChiKey: OULZEYQKBDXFKX-VEELZWTKSA-N

物化性质

• 熔点：
  148-153°C
• 溶解度：
  DMSO（少许）、甲醇（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY
  申请人：Tarroux Roger

  公开号：US20100240754A1

  公开（公告）日：2010-09-23

  The present invention relates to drugs consisting of unsaturated fatty amino-acid derivatives of the general formula (I), and to their pharmaceutically acceptable acid addition salts, in which: X is oxygen or NH, Rn are independently hydrogen or a (C 1 -C 6 )alkyl optionally substituted by halogen; R 1 is hydrogen, fluorine, chlorine or bromine, or a CF 3 or CHF 2 or a (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl or (C 1 -C 6 )alkynyl, optionally substituted by one or more halogen atoms; R is hydrogen or a (C 1 -C 6 )alkyl or (C 3 -C 6 )cycloalkyl optionally substituted by one or more halogen atoms; Ra and Rb are independently hydrogen (C 1 -C 6 )alkyl or (C 1 -C 6 )acyl, and Ra and Rb a hydrocarbonated cycle containing 4 to 6 carbon atoms; and n is an integer between 2 and 14.

  本发明涉及一种由通式（I）的不饱和脂肪氨基酸衍生物组成的药物，以及它们的药用可接受的酸盐，其中：X为氧或NH，Rn独立地为氢或经卤素取代的（C1-C6）烷基；R1为氢、氟、氯或溴，或者为CF3或CHF2或（C1-C6）烷基、（C1-C6）烯基或（C1-C6）炔基，可以经过一个或多个卤素原子的取代；R为氢或者经过一个或多个卤素原子取代的（C1-C6）烷基或（C3-C6）环烷基；Ra和Rb独立地为氢、（C1-C6）烷基或（C1-C6）酰基，而Ra和Rb为含有4到6个碳原子的碳氢化合物环；n为介于2和14之间的整数。
• Biochemical Synthesis of 6-Amino Caproic Acid
  申请人：Raemakers-Franken C. Petronella

  公开号：US20070254341A1

  公开（公告）日：2007-11-01

  The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells for being used in such biotransformation process, and to precursor fermentation of 6-amino caproic acid from intermediates leading to 6-amino caproic acid. Finally, the invention relates to certain novel biochemically produced compounds, namely 6-aminohex-2-enoic acid, 6-aminohexanoic acid, as well as to caprolactam produced therefrom and to nylon-6 and other derivatives produced from such biochemically produced compounds or caprolactam.

  本发明涉及通过用具有α，β-烯酸还原酶活性的酶处理含有α，β-烯酸基团和一级氨基团分子的6-氨基己-2-烯酸化合物或6-氨基-2-羟基己酸，从而生物化学合成6-氨基己酸。本发明还涉及用于此类生物转化过程的适用的基因工程细胞的获得过程，以及从导致6-氨基己酸的中间体中进行的前体发酵。最后，本发明涉及某些新型生物化学合成的化合物，即6-氨基己-2-烯酸、6-氨基己酸，以及由此产生的己内酰胺和从这样的生物化学合成的化合物或己内酰胺产生的尼龙-6和其他衍生物。
• Biochemical synthesis of 6-amino caproic acid
  申请人：Raemakers-Franken Petronella C.

  公开号：US20090137759A1

  公开（公告）日：2009-05-28

  The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells for being used in such biotransformation process, and to precursor fermentation of 6-amino caproic acid from intermediates leading to 6-amino caproic acid. Finally, the invention relates to certain novel biochemically produced compounds, namely 6-aminohex-2-enoic acid, 6-aminohexanoic acid, as well as to caprolactam produced therefrom and to nylon-6 and other derivatives produced from such biochemically produced compounds or caprolactam.

  本发明涉及从6-氨基己-2-烯酸化合物或从6-氨基-2-羟基己酸经由酶处理，该酶具有对含有α，β-烯酸基团和一级氨基的分子具有α，β-烯酸还原酶活性的生物化学合成6-氨基己酸的方法。本发明还涉及获得适用于此类生物转化过程的合适基因工程细胞的方法以及从导致6-氨基己酸的中间体中的前体发酵。最后，本发明涉及某些新型的生物化学合成的化合物，即6-氨基己-2-烯酸，6-氨基己酸，以及从中生产的己内酰胺和从这些生物化学合成化合物或己内酰胺生产的尼龙6和其他衍生物。
• Biochemical synthesis of 6 amino caproic acid
  申请人：DSM IP Assets B.V.

  公开号：EP2194139A1

  公开（公告）日：2010-06-09

  The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells for being used in such biotransformation process, and to precursor fermentation of 6-amino caproic acid from intermediates leading to 6-amino caproic acid. Finally, the invention relates to certain novel biochemically produced compounds, namely 6-aminohex-2-enoic acid, 6-aminohexanoic acid, as well as to caprolactam produced therefrom and to nylon-6 and other derivatives produced from such biochemically produced compounds or caprolactam.

  本发明涉及以 6-氨基己-2-烯酸化合物或 6-氨基-2-羟基己酸为原料，通过对含有 α，β-烯酸基和伯氨基的分子具有 α，β-烯酸还原酶活性的酶处理，生化合成 6-氨基己酸。 本发明还涉及获得用于这种生物转化过程的合适基因工程细胞的过程，以及从导致 6-氨基己酸的中间产物中发酵 6-氨基己酸的前体。 最后，本发明涉及某些新型生化生产的化合物，即 6-氨基己-2-烯酸、6-氨基己酸，以及由其生产的己内酰胺和由这种生化生产的化合物或己内酰胺生产的尼龙-6 和其他衍生物。
• BIOCHEMICAL SYNTHESIS OF 6-AMINO CAPROIC ACID
  申请人：DSM IP Assets B.V.

  公开号：EP1706501B1

  公开（公告）日：2010-01-13