N-methyl-2-[(1-phenyl-1,2-dihydro[1,4]oxazino[2,3,4-jk]carbazol-7-yl)oxy]-1-ethanamine maleic acid salt | 324817-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-methyl-2-[(1-phenyl-1,2-dihydro[1,4]oxazino[2,3,4-jk]carbazol-7-yl)oxy]-1-ethanamine maleic acid salt
• 英文别名: N-methyl-2-[(1-phenyl-1,2-dihydro[1,4]oxazino[2,3,4-jk]carbazol-7-yl)oxy]-1-ethanamine maleate；(Z)-but-2-enedioic acid;N-methyl-2-[(2-phenyl-4-oxa-1-azatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16),10(15),11,13-hexaen-11-yl)oxy]ethanamine
• CAS: 324817-49-4
• 化学式: C₄H₄O₄*C₂₃H₂₂N₂O₂
• 分子量: 474.513
• InChiKey: QZOIWWJHOOPANK-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.09
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Oxazinocarbazoles for the treatment of CNS diseases
  申请人：——

  公开号：US20020169317A1

  公开（公告）日：2002-11-14

  The present invention provides oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula (I) wherein R 1 , R 2 , R 3 and R 4 are described herein. 1 These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.

  本发明提供具有环连接位置8（C-8）和位置9（N-9）的噁唑卡巴祖衍生物，更具体地提供式（I）中R1，R2，R3和R4所描述的化合物。这些化合物是5-HT配体，可用于治疗需要调节5-HT活性的疾病。
• OXAZINOCARBAZOLES FOR THE TREATMENT OF CNS DISEASES
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1200447A1

  公开（公告）日：2002-05-02
• US6448397B1
  申请人：——

  公开号：US6448397B1

  公开（公告）日：2002-09-10
• [EN] OXAZINOCARBAZOLES FOR THE TREATMENT OF CNS DISEASES<br/>[FR] OXAZINOCARBAZOLES POUR LE TRAITEMENT DES MALADIES DU SNC
  申请人：UPJOHN CO

  公开号：WO2001009142A1

  公开（公告）日：2001-02-08

  The present invention provides oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula (I) wherein R1, R2, R3 and R4 are described herein. These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.