(R)-1,2-二(3,5-二氧代哌嗪-1-基)丙烷 | 24613-06-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-1,2-二(3,5-二氧代哌嗪-1-基)丙烷
• 英文名称: Levrazoxane
• 英文别名: ICRF-186；(R)-razoxane；dexrazoxane；(R)-(-)-1,2-bis(3,5-dioxopiperazin-1-yl)propane；(R)(-)-1,2-bis(3,5-dioxopiperazinyl)propane；Razoxane, (R)-；4-[(2R)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
• CAS: 24613-06-7
• 化学式: C₁₁H₁₆N₄O₄
• 分子量: 268.272
• InChiKey: BMKDZUISNHGIBY-SSDOTTSWSA-N

物化性质

• 沸点：
  531.5±50.0 °C(Predicted)
• 密度：
  1.333±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  98.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙亚胺 在 uncoated fused-silica capillaries of 50mm I_.D_. and a total length of 58.5 cm (50 cm effective length) with chiral carbosilane dendrimer functionalized with N-acetyl-L-cysteine (G₁Si(SCH₂CH(NHCOCH₃)(COOH))8) as chiral selector 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.15h， 生成 右雷佐生 、 (R)-1,2-二(3,5-二氧代哌嗪-1-基)丙烷
  参考文献：
  名称：

  Synthesis of chiral carbosilane dendrimers with l -cysteine and N -acetyl- l -cysteine on their surface and their application as chiral selectors for enantiomer separation by capillary electrophoresis

  摘要：

  The synthesis of chiral carbosilane dendrimers functionalized with cysteine and N-acetylcysteine groups is presented. These dendrimers were obtained through thiol-ene addition reactions and their application as chiral selectors in capillary electrophoresis was investigated. Four drugs used as model compounds were analyzed under different experimental conditions observing that the use of a first generation dendrimer containing 4 terminal N-acetyl-L-cysteine groups enabled the enantiomeric discrimination of razoxane with a discrimination power similar to that obtained with other powerful chiral selectors such as cyclodextrins. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2017.10.028

文献信息

• Novel Method for Producing 4,4-(1-Methyl-1,2-Ethanediyl)-BIS-(2,6-Piperazinedione)
  申请人：Koch Andreas

  公开号：US20100152447A1

  公开（公告）日：2010-06-17

  A method for preparing compounds of the formula (I) by the cyclization of tetraacetic acid alkyl esters of the formula (II) in the presence of ammonia and formamide as well as to the compounds of the formula (II), which are used in this method.

  一种通过在氨和甲酰胺存在下将化合物（II）的四乙酸烷基酯环化制备成式（I）的方法，以及在该方法中使用的化合物（II）。
• Prevention and treatment of cardiac conditions
  申请人：CROSS Maurice R.

  公开号：US20080275036A1

  公开（公告）日：2008-11-06

  The present invention provides a method of treating conditions associated with iron and calcium overload comprising administering an effective amount of dexrazoxane or a non-dexrazoxane compound of formula (IA), (IB), or (IC) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

  本发明提供了一种治疗与铁和钙过载相关症状的方法，包括给予有效量的地拉唑喜或公式（IA）、（IB）或（IC）的非地拉唑喜化合物或其药用可接受的盐、互变异构体或立体异构体。
• NEUES VERFAHREN ZUR HERSTELLUNG VON 4,4'-(1-METHYL-1,2-ETHANDIYL)-BIS-(2,6-PIPERAZINDION)
  申请人：Cyathus Exquirere Pharmaforschungs Gmbh

  公开号：EP2099773B1

  公开（公告）日：2017-07-05
• Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes
  申请人：ERBAMONT, INC.

  公开号：EP0330381B1

  公开（公告）日：1995-05-24
• US4963679A
  申请人：——

  公开号：US4963679A

  公开（公告）日：1990-10-16