[3-(2-Aminoethyl)-1-methylindol-5-yl]methanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [3-(2-Aminoethyl)-1-methylindol-5-yl]methanesulfonamide
• 化学式: C₁₂H₁₇N₃O₂S
• 分子量: 267.35
• InChiKey: AFEMXVQSZFPQSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  99.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 3-'2-(Dimethylamino) ethyl!-N-methyl-1H-indole-5-methanesulfonamide and the Succinate Thereof<br/>[FR] 3-'2-(DIMETHYLAMINO)ETHYL-N-METHYL-1H-INDOLE-5-METHANESULFONAMIDE ET SUCCINATE CORRESPONDANT
  申请人：REDDYS LAB LTD DR

  公开号：WO2003105836A1

  公开（公告）日：2003-12-24

  A process for the preparation of highly pure Sumatriptan is described. A process for the preparation of novel crystalline Form I and crystalline Form II of Sumatriptan succinate is described. Sumatriptan is used for alleviating the pain of migraine headaches.

  本文描述了制备高纯度舒马曲坦的过程。本文描述了制备舒马曲坦琥酸盐新晶体形式I和晶体形式II的过程。舒马曲坦用于缓解偏头痛的疼痛。
• Indole derivatives, their use as medicines and pharmaceutical compositions containing them
  申请人：GLAXO GROUP LIMITED

  公开号：EP0500086A1

  公开（公告）日：1992-08-26

  The invention relates to indoles of general formula (I): wherein R¹ represents a hydrogen atom or a C₁₋₆ alkyl or C₃₋₆ alkenyl group; R² represents a hydrogen atom, a C₁₋₃ alkyl or C₃₋₆ alkenyl group, an aryl or ar(C₁₋₄)alkylene group, or a C₅₋₇ cycloalkyl group; R³ represents a hydrogen atom or a C₁₋₃ alkyl group; R⁴ and R⁵, which may be the same of different, each represents a hydrogen atom or a C₁₋₃alkyl or 2-propenyl group, or R⁴ and R⁵ together form an aralkylidine group; R⁶ represents a C₁₋₆ alkyl or C₃₋₆alkenyl group and Alk represents an alkylene chain containing two or three carbons atoms which may be unsubstituted or substituted by not more than two C₁₋₃ alkyl groups, and physiologically acceptable salts and solvates (e.g. hydrates) thereof. Compounds of general formula (I) are useful in treating conditions associated with cephalic pain, in particular migraine.

  本发明涉及一般式（I）的吲哚化合物：其中R¹代表氢原子或C₁₋₆烷基或C₃₋₆烯基基团；R²代表氢原子，C₁₋₃烷基或C₃₋₆烯基基团，芳基或ar（C₁₋₄）烷基基团，或C₅₋₇环烷基；R³代表氢原子或C₁₋₃烷基基团；R⁴和R⁵，它们可以相同或不同，每个代表氢原子或C₁₋₃烷基或2-丙烯基基团，或R⁴和R⁵一起形成芳基烷基亚胺基团；R⁶代表C₁₋₆烷基或C₃₋₆烯基基团，Alk代表含有两个或三个碳原子的烷基链，可以未取代或被不超过两个C₁₋₃烷基基团取代，以及其生理上可接受的盐和溶剂（例如水合物）。一般式（I）的化合物对于治疗与头痛有关的疾病特别是偏头痛是有用的。
• 3-'2-(Dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
  申请人：Reddy Satyanarayana Manne

  公开号：US20060106227A1

  公开（公告）日：2006-05-18

  A process for the preparation of highly pure Sumatriptan id described. A process for the preparation of novel crystalline Form I and crystalline Form II of Sumatriptan succinate is described. Sumatriptan is used for alleviating the pain of migraine headaches.

  本发明描述了一种制备高纯度舒马曲坦的方法。本发明描述了一种制备舒马曲坦琥珀酸盐新晶体形式I和晶体形式II的方法。舒马曲坦用于缓解偏头痛疼痛。
• Process for the production of chemical compounds
  申请人：GLAXO GROUP LIMITED

  公开号：EP0145459A2

  公开（公告）日：1985-06-19

  A process is disclosed for the preparation of an indole of general formula (I) wherein R1 represents H or C1-6-alkyl or C3-6-alkenyl, R2 represents H or C1-3 alkyl, C3-6 alkenyl, aryl, ar(C1-4)alkyl or C5-7 cycloalkyl, R3 represents H or C1-3 alkyl group; R4 and R5, represent H or a C1-3 alkyl or propenyl group or together form an aralkylidene group; and Alk represents a C2-3 alkylene chain, or a physiologically acceptable salt or solvate thereof which comprises reacting an indole of general formula (II) : (wherein X represents a leaving group) with an amine R1R2NH. The indoles of formula (I) are indicated for use in the treatment of migraine.

  本发明公开了一种通式(I)吲哚的制备工艺 其中 R1 代表 H 或 C1-6- 烷基或 C3-6- 烯基、 R2 代表 H 或 C1-3 烷基、C3-6 烯基、芳基、ar(C1-4)烷基或 C5-7 环烷基、 R3 代表 H 或 C1-3 烷基； R4 和 R5 代表 H 或 C1-3 烷基或丙烯基，或共同组成亚芳烷基；以及 Alk 代表 C2-3 亚烷基链、 或其生理上可接受的盐或溶液，其中包括使通式 (II) ： (其中 X 代表离去基团）与胺 R1R2NH 反应。 式(I)的吲哚可用于治疗偏头痛。
• Preparation of indole derivatives
  申请人：GLAXO GROUP LIMITED

  公开号：EP0462837A2

  公开（公告）日：1991-12-27

  A method for the preparation of 3-(2-aminoethyl)-N-methyl-1H-indole-5-methanesulphonamide by reaction of 4-hydrazino-N-methylbenzenemethanesulphonamide and 4-chloro-1-hydroxybutanesulphonic acid, sodium salt in the presence of an acid.

  一种制备 3-(2-氨基乙基)-N-甲基-1H-吲哚-5-甲磺酰胺的方法，由 4-肼基-N-甲基苯甲磺酰胺和 4-氯-1-羟基丁磺酸钠盐在酸的存在下反应制得。