3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-phenyl-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-phenyl-1H-indole
• 化学式: C₂₂H₂₄N₂
• 分子量: 316.4
• InChiKey: OHCNOOMTAFPKKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] AZABICYCLE-SUBSTITUTED PHENYLINDOLE DERIVATIVES AS LIGANDS FOR 5-HT2A RECEPTORS<br/>[FR] DERIVES DE PHENYLINDOLE A SUBSTITUTION AZABICYCLIQUE EN TANT QUE LIGANDS DES RECEPTEURS 5-HT2A
  申请人：MERCK SHARP & DOHME

  公开号：WO2000004017A1

  公开（公告）日：2000-01-27

  Compounds of formula (I), or a salt thereof wherein the broken line represents an optional chemical bond; A and B independently represent hydrogen, halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy; C1-6alkyl or C1-6alkoxy; or A and B, when attached to adjacent carbon atoms, together represent methylenedioxy; X and Y independently represent hydrogen, halogen, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy or phenyl; Q represents a group of the formula -CH2CH2- or -CH2CH2CH2-; R1 represents hydrogen, C¿1-6?alkyl, or an optionally substituted aryl(C1-6)alkyl, heteroaryl(C1-6)alkyl or C3-7heterocycloalkyl(C1-6)alkyl group; and R?2¿ represents hydrogen, halogen. C¿1-6?alkyl, hydroxy or C1-6alkoxy are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including psychotic disorders such as schizophrenia.