(R)-1-苄基-吡咯烷-2-羰酰氯 | 105099-19-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-1-苄基-吡咯烷-2-羰酰氯
• 英文名称: 1-Benzylprolyl chloride
• 英文别名: 1-benzylpyrrolidine-2-carbonyl chloride
• CAS: 105099-19-2
• 化学式: C₁₂H₁₄ClNO
• 分子量: 223.7
• InChiKey: ZDTDYTRIYBAWEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
  申请人：Lead Therapeutics, Inc.

  公开号：EP2247600A2

  公开（公告）日：2010-11-10
• [EN] BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)<br/>[FR] INHIBITEURS À BASE DE COMPOSÉS BENZOXAZOLE-CARBOXAMIDE DE L'ACTIVITÉ POLY(ADP-RIBOSE)POLYMÉRASE (PARP)
  申请人：LEAD THERAPEUTICS INC

  公开号：WO2009099736A2

  公开（公告）日：2009-08-13

  A compound having the structure set forth in Formula (I) or Formula (II): Formula (I) Formula (II) wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.