(R)-2,3-二(十六烷氧基)丙烷-1-醇 | 1070-08-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: (R)-2,3-二(十六烷氧基)丙烷-1-醇
• 英文名称: 1,2-di-O-hexadecyl-sn-glyceride
• 英文别名: (R)-2,3-Bis(hexadecyloxy)-1-propanol；(2R)-2,3-dihexadecoxypropan-1-ol
• CAS: 1070-08-2
• 化学式: C₃₅H₇₂O₃
• 分子量: 540.955
• InChiKey: YQDJMFFVPVZWNK-PGUFJCEWSA-N

物化性质

• 熔点：
  37-38 °C
• 沸点：
  611.7±35.0 °C(Predicted)
• 密度：
  0.876±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.8
• 重原子数：
  38
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-2,3-二(十六烷氧基)丙烷-1-醇 生成 N,N'-dicyclohexylmorpholine-4-carboximidamide;[(2R)-2,3-dihexadecoxypropoxy]-morpholin-4-ylphosphinic acid
  参考文献：
  名称：

  BRACHWITZ, HANZ;JANTA-LIPINSKI, MARTIN

  摘要：

  DOI：
• 作为产物：
  描述：

  在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 水 为溶剂， 以95 %的产率得到(R)-2,3-二(十六烷氧基)丙烷-1-醇
  参考文献：
  名称：

  Archaeal Glycerolipids Are Recognized by C-Type Lectin Receptor Mincle

  摘要：

  DOI：

  10.1021/jacs.3c05473

文献信息

• Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin–lipid interactions
  作者：Jin Cui、Satoshi Kawatake、Yuichi Umegawa、Sébastien Lethu、Masaki Yamagami、Shigeru Matsuoka、Fuminori Sato、Nobuaki Matsumori、Michio Murata

  DOI：10.1039/c5ob01252j

  日期：——

  Phosphatidylglycerophosphate methyl ester (PGP-Me), a major constituent of the archaeal purple membrane, is essential for the proper proton-pump activity of bacteriorhodopsin (bR).

  磷脂甘油磷酸甲酯（PGP-Me）是古菌紫膜的主要成分，对于细菌紫质蛋白（bR）的正确质子泵活性至关重要。
• IMPROVED COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS
  申请人：TEKMIRA Pharmaceuticals Corporation

  公开号：EP2224912B1

  公开（公告）日：2016-05-11
• A versatile library of activity-based probes for fluorescence detection and/or affinity isolation of lipolytic enzymes
  作者：Heidrun Susani-Etzerodt、Hannes Schmidinger、Gernot Riesenhuber、Ruth Birner-Gruenberger、Albin Hermetter

  DOI：10.1016/j.chemphyslip.2006.06.018

  日期：2006.10

  This work describes the synthesis of a library of fluorescent and/or biotinylated alkylphosphonate inhibitors being reactive towards serine hydrolases, especially lipases and esterases. Fluorescent inhibitors can be used for sensitive and rapid detection of active proteins by gel electrophoresis. Biotinylated inhibitors are applicable for the enrichment and isolation of active enzymes. Functionality as well as the different detection methods of the synthesized inhibitors were successfully tested with an enzyme preparation, namely cholesterol esterase from porcine pancreas (ppCE). Moreover, a biotinylated inhibitor was employed to enrich ppCE on avidin beads. Hence, our set of phosphonate inhibitors can be used for the detection and/or isolation of active serine hydrolases. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
• Dérivés lipophiles de muramylpeptides ayant des propriétés d'activation des macrophages, compositions les contenant et procédé pour les obtenir
  申请人：ANVAR Agence Nationale de Valorisation de la Recherche

  公开号：EP0165123B1

  公开（公告）日：1990-08-08
• Fluorescent Phosphonic Ester Library
  申请人：Hermetter Albin

  公开号：US20080108508A1

  公开（公告）日：2008-05-08

  An assay library comprising 14 fluorescently labeled phosphonate esters which act as serine hydrolase inhibitors is provided as an analytical tool enabling activity based identification of serine hydrolases and characterization of enzyme preparations, protein mixtures and complex proteome samples.