7,10-Diazatetracyclo[8.7.1.05,18.011,17]octadeca-1,3,5(18)-triene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7,10-Diazatetracyclo[8.7.1.05,18.011,17]octadeca-1,3,5(18)-triene
• 化学式: C₁₆H₂₂N₂
• 分子量: 242.36
• InChiKey: YJLRAQZCPSWTII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives
  申请人：Sabb Louise Annmaire

  公开号：US20050054635A1

  公开（公告）日：2005-03-10

  This invention provides compounds of the formula: wherein R 1 and R 2 are each, independently, H, alkyl, cycloalkyl, —CH 2 -cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO 2 -alkyl, —SO 2 —NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, or phenoyl or thiophenoyl; R 3 and R 4 are each, independently, H, alkyl or cycloalkyl; R 5 is H or alkyl; R 6 is H or; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions and methods utilizing these compounds for the treatment or prevention of disorders including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

  本发明提供了式中化合物： 其中 R 1 和 R 2 各自独立地为 H、烷基、环烷基、-CH 2 -环烷基、烷氧基、卤素、氟化烷基、-CN、-NH-SO 2 -烷基、-SO 2 -NH-烷基、烷基酰胺、氨基、烷基氨基、二烷基氨基、氟化烷氧基、酰基或苯甲酰基或噻吩甲酰基；R 3 和 R 4 各自独立地为 H、烷基或环烷基； R 5 是 H 或烷基 6 或其药学上可接受的盐；以及利用这些化合物治疗或预防强迫症、抑郁症、焦虑症、广泛性焦虑症、精神分裂症、偏头痛、睡眠障碍、饮食失调、肥胖症、癫痫和脊髓损伤等疾病的药物组合物和方法。
• Cyclohepta [b] [1,4] diazepino [6,7, 1-hi] indoles and derivatives
  申请人：American Home Products Corporation

  公开号：US20020128261A1

  公开（公告）日：2002-09-12

  This invention provides compounds of the formula: 1 wherein R 1 and R 2 are each, independently, H, alkyl, cycloalkyl, —CH 2 -cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO 2 -alkyl, —SO 2 —NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, or phenoyl or thiophenoyl; R 3 and R 4 are each, independently, H, alkyl or cycloalkyl; R 5 is H or alkyl; R 6 is H or; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions and methods utilizing these compounds for the treatment or prevention of disorders including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.
• US6858604B2
  申请人：——

  公开号：US6858604B2

  公开（公告）日：2005-02-22
• US7271164B2
  申请人：——

  公开号：US7271164B2

  公开（公告）日：2007-09-18
• [EN] CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES<br/>[FR] CYCLOALKYL[B][1,4]DIAZEPINO[6,7,1-HI]INDOLES ET DERIVES
  申请人：WYETH CORP

  公开号：WO2002036596A2

  公开（公告）日：2002-05-10

  This invention provides cycloalkyl[1,4] diazepino[6,7,1-hi] indole compounds of the formula (I): or a pharmaceutically acceptable salt thereof, as well as methods and pharmaceutical compositions utilizing them for the treatment or prevention of disorders such as obsessive-compulsive disorder, depression, anxiety, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.