1h-Indole-3-acetic acid,1-[(4-chlorophenyl)methyl]-5-methoxy-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1h-Indole-3-acetic acid,1-[(4-chlorophenyl)methyl]-5-methoxy-
• 英文别名: 2-[1-[(4-chlorophenyl)methyl]-5-methoxyindol-3-yl]acetic acid
• 化学式: C₁₈H₁₆ClNO₃
• 分子量: 329.8
• InChiKey: XWVFVZXMCOPFOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] N-BENZYLINDOLE-3-ACETIC ACID DERIVATIVES FOR USE IN THE TREATMENT OF DRUG RESISTAN CANCER<br/>[FR] DERIVES D'ACIDE ACETIQUE N-BENZYLINDOLE-3 POUVANT ETRE UTILISES DANS LE TRAITEMENT DE CANCERS PHARMACORESISTANTS
  申请人：UNIV DUBLIN CITY

  公开号：WO2002020478A1

  公开（公告）日：2002-03-14

  A family of compounds, N-Benzylindoel-3-acetic acid derivatives, are active as inhibitors of multiple drug resistance protein (MRP) while having low direct toxicity, low COX -1 inhibitory activity and, in some cases, having useful activities such as COX-1 inhibition. The agents are useful in combination with MRP substrate drugs in the treatment of, for example, drug resistant cancer or tumours likely to develop drug resistant cancers because they can be given at higher concentration while being less toxic and having less side effects than known MRP inhibitors. The agents may also be more beneficial in the treatment of diseases which are dependent on MRP-1 activity or where MRP-1 activity reduces the effectiveness of existing therapies.