[3-(3-amino-4-methoxyphenyl)-4-methoxy-1H-indol-2-yl]-(3,4,5-trimethoxyphenyl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [3-(3-amino-4-methoxyphenyl)-4-methoxy-1H-indol-2-yl]-(3,4,5-trimethoxyphenyl)methanone
• 化学式: C₂₆H₂₆N₂O₆
• 分子量: 462.5
• InChiKey: NMDSRRXPIKXOOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• INDOLE-CONTAINING AND COMBRETASTATIN-RELATED ANTI-MITOTIC AND ANTI-TUBULIN POLYMERIZATION AGENTS
  申请人：BAYLOR UNIVERSITY

  公开号：EP1214298A2

  公开（公告）日：2002-06-19
• US6849656B1
  申请人：——

  公开号：US6849656B1

  公开（公告）日：2005-02-01
• [EN] INDOLE-CONTAINING AND COMBRETASTATIN-RELATED ANTI-MITOTIC AND ANTI-TUBULIN POLYMERIZATION AGENTS<br/>[FR] AGENTS DE POLYMERISATION ANTIMITOTIQUES ET ANTITUBULINES CONTENANT DE L'INDOLE ET APPARENTES A LA COMBRETASTATINE
  申请人：UNIV BAYLOR

  公开号：WO2001019794A2

  公开（公告）日：2001-03-22

  Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting and destruction chemotherapeutic agents or to have anti-angiogenesis activity resulting in the selective prevention and/or destruction of tumor cell vasculature.