7-Fluor-5-<4-chlor-phenyl>-1-methyl-1.3-dihydro-2H-1.4-benzodiazepin-2-on | 1959-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-Fluor-5-<4-chlor-phenyl>-1-methyl-1.3-dihydro-2H-1.4-benzodiazepin-2-on
• 英文别名: Ro 5-6531；5-(4-chloro-phenyl)-7-fluoro-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one；5-(4-chlorophenyl)-7-fluoro-1-methyl-3H-1,4-benzodiazepin-2(1H)-one；1,4-Benzodiazpn2-ON,1-ME5(4-clph)7F；5-(4-chlorophenyl)-7-fluoro-1-methyl-3H-1,4-benzodiazepin-2-one
• CAS: 1959-97-3
• 化学式: C₁₆H₁₂ClFN₂O
• 分子量: 302.735
• InChiKey: BOAYIEYBUOMKDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection
  申请人：Goeders Nicholas E.

  公开号：US10022383B2

  公开（公告）日：2018-07-17

  A method of treating a condition of in a human patient comprising pharmacologically activating a translocator protein of 18 kDa (TSPO), wherein the condition is one of a chronic methamphetamine addiction, a medical consequence of methamphetamine use; a behavioral consequence of methamphetamine use, an HIV associated cognitive motor disorder, an HIV-associated neurodegenerative disorder, and a neuroinflammatory response.

  一种治疗人类患者病症的方法，包括药理激活 18 kDa 转运体蛋白（TSPO），其中所述病症为慢性甲基苯丙胺成瘾、使用甲基苯丙胺的医疗后果、使用甲基苯丙胺的行为后果、HIV 相关认知运动障碍、HIV 相关神经退行性障碍和神经炎症反应中的一种。
• DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION
  申请人：GOEDERS Nicholas E.

  公开号：US20160367565A1

  公开（公告）日：2016-12-22

  A method of treating a condition of in a human patient comprising pharmacologically activating a translocator protein of 18 kDa (TSPO), wherein the condition is one of a chronic methamphetamine addiction, a medical consequence of methamphetamine use; a behavioral consequence of methamphetamine use, an HIV associated cognitive motor disorder, an HIV-associated neurodegenerative disorder, and a neuroinflammatory response.
• US4898861A
  申请人：——

  公开号：US4898861A

  公开（公告）日：1990-02-06