Ethyl 9-[3-(4-hydroxy-4-phenylpiperidin-1-yl)propyl]pyrido[3,4-b]indole-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Ethyl 9-[3-(4-hydroxy-4-phenylpiperidin-1-yl)propyl]pyrido[3,4-b]indole-3-carboxylate
• 化学式: C₂₈H₃₁N₃O₃
• 分子量: 457.6
• InChiKey: UTFXQJCYWALWTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  67.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] BETA-CARBOLINE DERIVATIVES FOR USE AS ANALGESICS<br/>[FR] DERIVES DE BETA-CARBOLINE UTILISES COMME ANALGESIQUES
  申请人：BRITISH TECH GROUP INT

  公开号：WO2001032176A1

  公开（公告）日：2001-05-10

  Compounds of formula (2) wherein n is 2, 3 or 4; Z is an ester group of formula R3-O-CO- wherein R3 is C¿1-6? alkyl or C2-6 alkenyl; and R?1, R2 and R5¿ are independently selected from the group consisting of hydrogen, halogen, hydroxy, methoxy, nitro, and trifluoromethyl; R4 is hydrogen or C¿1-6? alkyl; in the form of the free base or an acid addition salt thereof are useful as GAT-3/4 type GABA uptake inhibitors, primarily to treat pain.