[3-[2-(Dimethylamino)ethyl]-1-methylindol-5-yl]methanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [3-[2-(Dimethylamino)ethyl]-1-methylindol-5-yl]methanesulfonamide
• 化学式: C₁₄H₂₁N₃O₂S
• 分子量: 295.4
• InChiKey: RRKUQERIXNCEFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Use of tachykinin antagonists in combination with serotonin agonists or serotonin reuptake inhibitors for the manufacture of a medicament for the treatment of allergic rhinitis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0747049A1

  公开（公告）日：1996-12-11

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a combination of a tachykinin receptor antagonist and either a serotonin agonist or a selective serotonin reuptake inhibitor. This administration may be concurrent or sequential, with either of the two activities being administered first.

  这项发明提供了治疗普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种缓释肽受体拮抗剂和5-羟色胺激动剂或选择性5-羟色胺再摄取抑制剂的组合。这种给药可以同时进行或顺序进行，两种活性中的任何一种都可以首先给予。
• Active agent delivery systems and methods for protecting and administering active agents
  申请人：New River Pharmaceuticals Inc.

  公开号：US20040063628A1

  公开（公告）日：2004-04-01

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性物质输送系统，更具体地涉及包含氨基酸，作为单个氨基酸或肽的组成部分，与活性物质共价连接的组合物和用于给予共轭活性物质组合物的方法。
• [EN] 3-'2-(Dimethylamino) ethyl!-N-methyl-1H-indole-5-methanesulfonamide and the Succinate Thereof<br/>[FR] 3-'2-(DIMETHYLAMINO)ETHYL-N-METHYL-1H-INDOLE-5-METHANESULFONAMIDE ET SUCCINATE CORRESPONDANT
  申请人：REDDYS LAB LTD DR

  公开号：WO2003105836A1

  公开（公告）日：2003-12-24

  A process for the preparation of highly pure Sumatriptan is described. A process for the preparation of novel crystalline Form I and crystalline Form II of Sumatriptan succinate is described. Sumatriptan is used for alleviating the pain of migraine headaches.

  本文描述了制备高纯度舒马曲坦的过程。本文描述了制备舒马曲坦琥酸盐新晶体形式I和晶体形式II的过程。舒马曲坦用于缓解偏头痛的疼痛。
• Indole derivatives, their use as medicines and pharmaceutical compositions containing them
  申请人：GLAXO GROUP LIMITED

  公开号：EP0500086A1

  公开（公告）日：1992-08-26

  The invention relates to indoles of general formula (I): wherein R¹ represents a hydrogen atom or a C₁₋₆ alkyl or C₃₋₆ alkenyl group; R² represents a hydrogen atom, a C₁₋₃ alkyl or C₃₋₆ alkenyl group, an aryl or ar(C₁₋₄)alkylene group, or a C₅₋₇ cycloalkyl group; R³ represents a hydrogen atom or a C₁₋₃ alkyl group; R⁴ and R⁵, which may be the same of different, each represents a hydrogen atom or a C₁₋₃alkyl or 2-propenyl group, or R⁴ and R⁵ together form an aralkylidine group; R⁶ represents a C₁₋₆ alkyl or C₃₋₆alkenyl group and Alk represents an alkylene chain containing two or three carbons atoms which may be unsubstituted or substituted by not more than two C₁₋₃ alkyl groups, and physiologically acceptable salts and solvates (e.g. hydrates) thereof. Compounds of general formula (I) are useful in treating conditions associated with cephalic pain, in particular migraine.

  本发明涉及一般式（I）的吲哚化合物：其中R¹代表氢原子或C₁₋₆烷基或C₃₋₆烯基基团；R²代表氢原子，C₁₋₃烷基或C₃₋₆烯基基团，芳基或ar（C₁₋₄）烷基基团，或C₅₋₇环烷基；R³代表氢原子或C₁₋₃烷基基团；R⁴和R⁵，它们可以相同或不同，每个代表氢原子或C₁₋₃烷基或2-丙烯基基团，或R⁴和R⁵一起形成芳基烷基亚胺基团；R⁶代表C₁₋₆烷基或C₃₋₆烯基基团，Alk代表含有两个或三个碳原子的烷基链，可以未取代或被不超过两个C₁₋₃烷基基团取代，以及其生理上可接受的盐和溶剂（例如水合物）。一般式（I）的化合物对于治疗与头痛有关的疾病特别是偏头痛是有用的。
• 3-'2-(Dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
  申请人：Reddy Satyanarayana Manne

  公开号：US20060106227A1

  公开（公告）日：2006-05-18

  A process for the preparation of highly pure Sumatriptan id described. A process for the preparation of novel crystalline Form I and crystalline Form II of Sumatriptan succinate is described. Sumatriptan is used for alleviating the pain of migraine headaches.

  本发明描述了一种制备高纯度舒马曲坦的方法。本发明描述了一种制备舒马曲坦琥珀酸盐新晶体形式I和晶体形式II的方法。舒马曲坦用于缓解偏头痛疼痛。