(15R,16R,18S)-16-(hydroxymethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-3,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (15R,16R,18S)-16-(hydroxymethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-3,5-dione
• 化学式: C₂₅H₁₇N₃O₄
• 分子量: 423.4
• InChiKey: NVSJOASGKCGXBZ-SYLNULQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  1
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Micelle containing epirubicin-complexed block copolymer and anti-cancer agent, and pharmaceutical composition containing said micelle applicable to treatment of cancer, resistant cancer or metastatic cancer
  申请人：The University of Tokyo

  公开号：US10220026B2

  公开（公告）日：2019-03-05

  The problem addressed by the present invention is to develop a pharmaceutical having therapeutic efficacy against epirubicin-resistant tumors. The present invention provides a micelle having an anti-cancer agent disposed inside the core of the micelle formed by an epirubicin-conjugated copolymer.

  本发明所要解决的问题是开发一种对表柔比星耐药性肿瘤具有疗效的药物。本发明提供了一种胶束，其抗癌剂被置于由表柔比星共聚物形成的胶束核心内。