(硝基亚氨基)二乙烯二异氰酸酯 | 7046-61-9

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 中文名称: (硝基亚氨基)二乙烯二异氰酸酯
• 英文名称: 3-Nitraza-1,5-pentan-diisocyanat
• 英文别名: Ethanamine, 2-isocyanato-N-(2-isocyanatoethyl)-N-nitro-；N,N-bis(2-isocyanatoethyl)nitramide
• CAS: 7046-61-9
• 化学式: C₆H₈N₄O₄
• 分子量: 200.154
• InChiKey: PMZAXZNFRDOMGE-UHFFFAOYSA-N

物化性质

• 沸点：
  337.86°C (rough estimate)
• 密度：
  1.5359 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (硝基亚氨基)二乙烯二异氰酸酯 在 iron(III)-acetylacetonate 作用下， 以 氯仿 为溶剂， 生成 Nitramin-bis-

  参考文献：

  名称：

  Frankel,M.B., Tetrahedron, Supplement, 1963, vol. 4, p. 213 - 217

  摘要：

  DOI：

文献信息

• Purification of oligonucleotides
  申请人：——

  公开号：US20030153742A1

  公开（公告）日：2003-08-14

  Methods and compounds useful for the purification of oligonucleotides and their analogs are provided wherein the oligonucleotides are contaminated with at least one oligonucleotide having at least one abasic site by the formation of imines at the aldehyde moiety of the abasic site and subsequent separation based on extractions, precipitations or chromatography.

  本发明提供了用于纯化寡核苷酸及其类似物的方法和化合物，其中寡核苷酸被至少一种具有至少一个消旋位点的寡核苷酸污染，方法是在消旋位点的醛基上形成亚胺，然后根据萃取、沉淀或色谱法进行分离。
• Synthesis of potential anticancer agents. 38. N-nitrosoureas. 4. Further synthesis and evaluation of haloethyl derivatives
  作者：Thomas P. Johnston、George S. McCaler、Pamela S. Opliger、W. Russell Laster、John A. Montgomery

  DOI：10.1021/jm00289a011

  日期：1971.7
• NEW FUNCTIONALIZED POLYMERIC REAGENTS
  申请人：AstraZeneca AB

  公开号：EP1239949A1

  公开（公告）日：2002-09-18
• US6586586B1
  申请人：——

  公开号：US6586586B1

  公开（公告）日：2003-07-01
• [EN] NEW FUNCTIONALIZED POLYMERIC REAGENTS<br/>[FR] NOUVEAUX REACTIFS POLYMERES FONCTIONNALISES
  申请人：ASTRAZENECA AB

  公开号：WO2001037983A1

  公开（公告）日：2001-05-31

  The present invention relates to functionalized polymeric reagents useful in solution and solid-phase synthesis. It relates more specifically to functionlized polymeric reagent, comprising an acid labile isonitrile moiety. In further aspects the present invention also relates to use of such functionalized polymeric reagent in solution and solid-phase synthesis, a method for preparing an organic compound by solution and solid-phase synthesis using such functionalized polymeric reagent, a method for preparing such functionalized polymeric reagent and to kits comprising the functionalized polymeric reagent of the invention. The present invention also relates to new intermediates for use in the preparation of the novel functionalized polymeric reagent. In one aspect, the present invention provides a functionalized polymeric reagent for use in solution and solid-phase synthesis, e.g. multicomponent reactions. The functionalized polymeric reagent comprises a linker, and said linker comprises an acid labile isonitrile moiety. The linker is covalently attached to the polymeric support.