(2R,4S)-4-methyl glutamic acid di-tert-butyl ester | 441311-23-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,4S)-4-methyl glutamic acid di-tert-butyl ester
• 英文别名: ditert-butyl (2R,4S)-2-amino-4-methylpentanedioate
• CAS: 441311-23-5
• 化学式: C₁₄H₂₇NO₄
• 分子量: 273.373
• InChiKey: HABDZZLONLIEPN-VHSXEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2R,4S)-N-Benzyloxycarbonyl-4-Methyl Glutamic Acid Di-tert-butyl Ester 在 钯 氢气 作用下， 以 乙酸乙酯 为溶剂， 以12 (30 mg, 50%) was obtained as a light yellow syrup的产率得到(2R,4S)-4-methyl glutamic acid di-tert-butyl ester
  参考文献：
  名称：

  Esters of alkycarboxy amino acids as prodrugs of modulators of the kainate receptor

  摘要：

  本发明涉及一类丙基羧基氨基酸类谷氨酸类似物的前药化合物，其作为kainate EAA受体阳离子通道的特异性调节剂。这些化合物适用于治疗与离子型EAA受体的kainate亚型的过度或不足激活相关的神经学、神经心理学、神经精神学、神经退行性、神经精神药理学和功能性障碍；治疗与kainate受体的去活化、亚最佳活化或过度激活相关的认知障碍；减轻疼痛并改善和增强记忆、学习和相关的心理过程。

  公开号：

  US20020115721A1

文献信息

• [EN] ESTERS OF ALKYLCARBOXY AMINO ACIDS AS PRODRUGS OF MODULATORS OF THE KAINATE RECEPTOR<br/>[FR] ESTERS D'AMINOACIDES ALKYLCARBOXY UTILES EN TANT QUE PROMEDICAMENTS DES MODULATEURS DES RECEPTEURS DE KANAITE
  申请人：ANNOVIS INC

  公开号：WO2002055479A2

  公开（公告）日：2002-07-18

  Disclosed are prodrug compounds of a class of alkyl carboxy amino acid analogs of glutamic acid that act as specific regulators of the kainate EAA receptor cation channel. These compounds are useful for treating neurological, neuropsychological, neuropsychiatric, neurodegenerative, neuropsychopharmacological and functional disorders associated with excessive or insufficient activation of the kainate subtype of the ionotropic EAA receptors; treating cognitive disorders associated with deactivation, suboptimal activation or over-activation of the kainate receptor; alleviating pain and improving and enhancing memory, learning, and associated mental processes.
• Esters of alkycarboxy amino acids as prodrugs of modulators of the kainate receptor
  申请人：Annovis, Inc.

  公开号：US20020115721A1

  公开（公告）日：2002-08-22

  Disclosed are prodrug compounds of a class of alkyl carboxy amino acid analogs of glutamic acid that act as specific regulators of the kainate EAA receptor cation channel. These compounds are useful for treating neurological, neuropsychological, neuropsychiatric, neurodegenerative, neuropsychopharmacological and functional disorders associated with excessive or insufficient activation of the kainate subtype of the ionotropic EAA receptors; treating cognitive disorders associated with deactivation, suboptimal activation or over-activation of the kainate receptor; alleviating pain and improving and enhancing memory, learning, and associated mental processes.

  本发明涉及一类丙基羧基氨基酸类谷氨酸类似物的前药化合物，它们作为特异性调节kainate EAA受体阳离子通道的调节剂。这些化合物可用于治疗与离子型EAA受体kainate亚型过度或不足激活相关的神经、神经心理、神经精神、神经退行性、神经精神药理学和功能障碍；治疗与kainate受体去活化、亚最佳激活或过度激活相关的认知障碍；缓解疼痛并改善和增强记忆、学习和相关的心理过程。