(+/-)-3-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-3-fluoro-7-(trifluoromethyl)-2H-indol-2-one | 385764-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (+/-)-3-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-3-fluoro-7-(trifluoromethyl)-2H-indol-2-one
• 英文别名: 3-(5-chloro-2-hydroxyphenyl)-3-fluoro-7-(trifluoromethyl)-1H-indol-2-one
• CAS: 385764-41-0
• 化学式: C₁₅H₈ClF₄NO₂
• 分子量: 345.681
• InChiKey: LJNPAPHLLPSUFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Use of 3-substituted oxindole derivatives as kcnq potassium channel modulators
  申请人：——

  公开号：US20030181507A1

  公开（公告）日：2003-09-25

  The present invention relates to a novel method of treating of pain or anxiety, using compounds that modulate KCNQ potassium channels and currents. 1

  本发明涉及一种治疗疼痛或焦虑的新方法，使用调节KCNQ钾通道和电流的化合物。
• Use of 3-substituted oxindole derivatives as KCNQ potassium channel modulators
  申请人：NEUROSEARCH A/S

  公开号：EP1634594A1

  公开（公告）日：2006-03-15

  The present invention relates to the use of substituted 3-phenyl oxindole derivatives as modulators of the potassium KCNQ channels, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.

  本发明涉及取代的 3-苯基吲哚衍生物作为 KCNQ 钾通道调节剂的用途、包含这些化合物的药物组合物以及治疗方法。
• USE OF 3-SUBSTITUTED OXINDOLE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS
  申请人：NEUROSEARCH A/S

  公开号：EP1303269B1

  公开（公告）日：2005-12-07
• [EN] USE OF 3-SUBSTITUTED OXINDOLE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS<br/>[FR] UTILISATION DE DERIVES D'OXINDOLE 3-SUBSTITUE COMME MODULATEURS DU CANAL POTASSIQUE KCNQ
  申请人：NEUROSEARCH AS

  公开号：WO2002000217A1

  公开（公告）日：2002-01-03

  The present invention relates to the use of substituted 3-phenyl oxindole derivatives having general formula (I), as modulators of the potassium KCNQ channels, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.