3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indole
• 化学式: C₂₀H₂₅N₅O
• 分子量: 351.4
• InChiKey: FXTWFBRXNCIKQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION
  申请人：KRAMER Stephen J.

  公开号：US20090281114A1

  公开（公告）日：2009-11-12

  The present invention relates to a method for alleviation, prevention, and treatment of anxiety, depression, and sexual dysfunction by administering certain indolylalkyl derivatives of pyrimidinylpiperazine or metabolites thereof. A preferred embodiment is of the following formula:

  本发明涉及通过给予某些吡咯啉基吡咯嗪的衍生物或其代谢物来缓解、预防和治疗焦虑、抑郁和性功能障碍的方法。一种首选实施例的化学式如下：
• 1-Indolylalkyl-4-(alkoxy-pyrimidinyl)piperazines
  申请人：Bristol-Myers Squibb Company

  公开号：EP0464604A2

  公开（公告）日：1992-01-08

  Certain 1-indolylalkyl-4-(alkoxypyrimidinyl) piperazines are useful antidepressant compounds.

  某些 1-吲哚烷基-4-(烷氧基嘧啶基)哌嗪是有用的抗抑郁化合物。
• Antimigraine alkoxypyrimidine derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：EP0464558A1

  公开（公告）日：1992-01-08

  Certain 1-indolylalkyl-4-[4-(5-alkoxy)-pyrimidinyl] piperazines and their pharmaceutically acceptable salts are useful in the treatment of vascular headache.

  某些 1-吲哚烷基-4-[4-(5-烷氧基)-嘧啶基]哌嗪及其药学上可接受的盐类可用于治疗血管性头痛。
• Extended release compositions
  申请人：Kramer J. Stephen

  公开号：US20050095286A1

  公开（公告）日：2005-05-05

  A pharmaceutical composition is provided, which includes: at least one active ingredient selected from the group including adatanserin, a compound having formula I, a compound having formula II, abaperidone, pharmaceutically acceptable salt thereof, prodrug thereof, and a mixture thereof; at least one high or medium viscosity hydroxypropylmethylcellulose (HPMC); at least one high or medium viscosity hydroxyethylcellulose (HEC); wherein the HPMC and HEC are present in a HPMC/HEC weight ratio ranging from 1/0.5 to 1/1.5; wherein adatanserin, abaperidone, and the compounds having formulas (I) and (II) are defined herein.

  本发明提供了一种药物组合物，其中包括：至少一种选自包括阿达坦色林、具有式 I 的化合物、具有式 II 的化合物、阿巴匹酮、其药学上可接受的盐、其原药及其混合物的活性成分；至少一种高粘度或中等粘度羟丙基甲基纤维素（HPMC）；至少一种高粘度或中等粘度羟乙基纤维素（HEC）；其中，HPMC 和 HEC 的 HPMC/HEC 重量比为 1/0.5至1/1.5；其中阿达坦色林、阿巴匹利酮和具有式(I)和(II)的化合物在本文中定义。
• IMIDAZOLE DERIVATIVES AND THEIR USE AS ACYL COENZYME-A INHIBITORS
  申请人：RHONE-POULENC SANTE

  公开号：EP0505468B1

  公开（公告）日：1995-04-26