5-(4-aminophenyl)-7-[2-(3,4-dimethoxyphenyl)-3-[ethyl(methyl)amino]propanoyl]-8-methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-8-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 5-(4-aminophenyl)-7-[2-(3,4-dimethoxyphenyl)-3-[ethyl(methyl)amino]propanoyl]-8-methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-8-carbonitrile
• 化学式: C₃₂H₃₅N₅O₅
• 分子量: 569.6
• InChiKey: LLJGRAPWPWBSRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] USE OF CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF DISEASES RELATED TO THE INHIBITION OF LIPID PEROXIDATION<br/>[FR] UTILISATION DE DERIVES DE 2,3-BENZODIAZEPINE POUR LE TRAITEMENT ET LA PREVENTION DE MALADIES LIEES A L'INHIBITION DE PEROXYDATION LIPIDIQUE
  申请人：EGYT GYOGYSZERVEGYESZETI GYAR

  公开号：WO2000053166A2

  公开（公告）日：2000-09-14

  The invention relates to the use of 8-substituted-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts and quaternary ammonium derivatives thereof for the preparation of pharmaceutical compositions suitable for the treatment or prophylaxis of diseases and states related to increased (pathological) lipid peroxidation and diseases caused by increased production of free radicals, e.g. atherosclerosis, pancreatitis, rheumatoid arthritis, cataract, Parkinson's disease, inflammatory diseases (e.g. hepatitis), ischemic heart disease, cerebral ischemia and renal failure.