异芒果苷 | 24699-16-9

• 物质功能分类: 生物化工 - 提取物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 异芒果苷
• 中文别名: 异杞果素
• 英文名称: 4-β-D-glucopyranosyl-1,3-6,7-tetrahydroxy-9H-xanthen-9-one
• 英文别名: 1,3,6,7-terahydroxyxanthone 4-C-glucoside；isomagniferin；isomangiferin；1,3,6,7-tetrahydroxyxanthone-4-C-glucoside；iso-mangiferin；1,3,6,7-tetrahydroxy-4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one
• CAS: 24699-16-9
• 化学式: C₁₉H₁₈O₁₁
• 分子量: 422.345
• InChiKey: CDYBOKJASDEORM-HBVDJMOISA-N

物化性质

• 沸点：
  798.8±60.0 °C(Predicted)
• 密度：
  1.843
• 溶解度：
  溶于氯仿和甲烷

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  197
• 氢给体数：
  8
• 氢受体数：
  11

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

生物活性

异芒果苷（Isomangiferin）是一种天然化合物，具有显著的抗病毒作用。

化学性质

它表现为微黄色小针晶，并能溶于甲醇、乙醇和DMSO等有机溶剂。这种化合物来源于芒果。

用途

异芒果苷不仅具有良好的镇咳祛痰效果，还具备强心、利尿及抗抑郁的作用。此外，它还可用于含量测定、鉴定以及药理实验等方面。

药理药效

异芒果苷表现出较强的镇咳祛痰效果，并且有显著的强心、利尿和抗抑郁作用。

反应信息

• 作为产物：
  描述：

  maclurin 3-C-(2''-O-galloyl-6''-O-p-hydroxybenzoyl)-β-D-glucoside 在 sodium carbonate 、 potassium hexacyanoferrate(III) 作用下， 以 水 为溶剂， 反应 2.0h， 生成 异芒果苷
  参考文献：
  名称：

  Tanaka, Takashi; Sueyasu, Tokiko; Nonaka, Gen-ichiro, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 7, p. 2676 - 2686

  摘要：

  DOI：

文献信息

• New Compounds from Siberian Gentiana Species. II. Xanthone and C,O-Glycosylflavone
  作者：D. N. Olennikov、N. K. Chirikova

  DOI：10.1007/s10600-021-03449-0

  日期：2021.7

  New phenolic compounds were isolated by chromatographic separation of MeOH extracts from leaves of two Gentiana species growing in eastern Siberia. Their structures were elucidated by UV and NMR spectroscopy and mass spectrometry. The new xanthone isomangiferin-7-O-β-D-glucopyranoside (neoisomangiferin) was isolated from G. dahurica Fisch.. A new C,O-glycosylflavone, apigenin-6-C-[2″-O-(6″″-O-caffeyl)-β-D-glucopyranosyl]-β-D-glucopyranoside-4′-O-β-D-glucopyranoside (gentiflavone A) was observed in G. macrophylla Pall.

  通过对西伯利亚东部两种龙胆属植物叶子中的甲醇提取物进行色谱分离，分离出新的酚类化合物。它们的结构通过紫外、核磁共振光谱和质谱得以阐明。从 G. dahurica Fisch 中分离得到新的呫吨酮 isomangiferin-7-O-β-D-glucopyranoside (neoisomangiferin)。一种新的 C,O-糖基黄酮，apigenin-6-C-[2″-O-(6″″) -O-咖啡基）-β-D-吡喃葡萄糖基]-β-D-吡喃葡萄糖苷-4'-O-β-D-吡喃葡萄糖苷（龙胆黄酮 A）在 G. macrophylla Pall 中观察到。
• LIGHT-COLORED ROSIN AND ROSIN ESTER COMPOSITIONS
  申请人：Kraton Polymers LLC

  公开号：EP3670619A2

  公开（公告）日：2020-06-24

  A three-step method to prepare a light-colored rosin ester is disclosed wherein at least in one of the steps (a) and (c) a co-catalyst is applied and wherein at least in one of the steps (a) and (c) a disproportionation catalyst is applied. In the second step, a distilled rosin is obtained which is esterified with a polyol into a light-colored rosin ester. In one embodiment, the co-catalyst has a triplet formation quantum yield (φT) of greater than 0.5 and a triplet lifetime (τT) of greater than 0.5 microseconds. In another embodiment, the co-catalyst is selected from acridone, anthrone, 9-fluorenone, thioxanthone, xanthone, derivatives and combinations thereof.

  本发明公开了一种制备浅色松香酯的三步法，其中(a)和(c)步骤中至少有一步使用了助催化剂，(a)和(c)步骤中至少有一步使用了歧化催化剂。在第二步中，得到蒸馏松香，该松香与多元醇酯化成浅色松香酯。在一个实施方案中，助催化剂的三重态形成量子产率（φT）大于 0.5，三重态寿命（τT）大于 0.5 微秒。在另一个实施方案中，助催化剂选自吖啶酮、蒽酮、9-芴酮、硫氧蒽酮、氧蒽酮、衍生物及其组合。
• Light rosin ester compositions and methods of making same
  申请人：KRATON POLYMERS LLC

  公开号：US10611926B2

  公开（公告）日：2020-04-07

  A light color or a low color rosin or a rosin ester composition is disclosed. Significant color improvement can be obtained for a low color rosin, or a rosin ester by using a co-catalyst. In one embodiment, the co-catalyst has a triplet formation quantum yield (ϕT) of greater than 0.5 and a triplet lifetime (τT) of greater than 0.5 microseconds In another embodiment, the co-catalyst is selected from acridone, anthrone, 9-fluorenone, thioxanthone, xanthone, derivatives and combinations thereof.

  本发明公开了一种浅色或低色松香或松香酯组合物。使用助催化剂可显著改善低色度松香或松香酯的色泽。在一个实施方案中，助催化剂的三重态形成量子产率 (ϕT)大于 0.5，三重态寿命 (τT)大于 0.5 微秒。在另一个实施方案中，助催化剂选自吖啶酮、蒽酮、9-芴酮、硫氧蒽酮、氧蒽酮、衍生物及其组合。
• Light-colored rosin and rosin ester compositions
  申请人：KRATON POLYMERS LLC

  公开号：US11034858B2

  公开（公告）日：2021-06-15

  A three-step method to prepare a light-colored rosin ester is disclosed wherein at least in one of the steps (a) and (c) a co-catalyst is applied and wherein at least in one of the steps (a) and (c) a disproportionation catalyst is applied. In the second step, a distilled rosin is obtained which is esterified with a polyol into a light-colored rosin ester. In one embodiment, the co-catalyst has a triplet formation quantum yield (ϕT) of greater than 0.5 and a triplet lifetime (τT) of greater than 0.5 microseconds. In another embodiment, the co-catalyst is selected from acridone, anthrone, 9-fluorenone, thioxanthone, xanthone, derivatives and combinations thereof.

  本发明公开了一种制备浅色松香酯的三步法，其中(a)和(c)步骤中至少有一步使用了助催化剂，(a)和(c)步骤中至少有一步使用了歧化催化剂。在第二步中，得到蒸馏松香，该松香与多元醇酯化成浅色松香酯。在一个实施方案中，助催化剂的三重态形成量子产率 (ϕT)大于 0.5，三重态寿命 (τT)大于 0.5 微秒。在另一个实施方案中，助催化剂选自吖啶酮、蒽酮、9-芴酮、硫氧蒽酮、氧蒽酮、衍生物及其组合。
• Light color rosin ester compositions and methods of making same
  申请人：KRATON POLYMERS LLC

  公开号：US11111411B2

  公开（公告）日：2021-09-07

  The disclosure relates to a light color or a low color rosin or a rosin ester composition. The rosin ester comprises a reaction product of one or more rosins, one or more polyhydric alcohols, and optionally one or more monocarboxylic acids, and optionally one or more polycarboxylic acids having from 2 to 54 carbon atoms; from 0 ppm to 200 ppm of a co-catalyst, and optionally, a disproportionation catalyst, an esterification catalyst, or combinations thereof. The co-catalyst has a triplet formation quantum yield (ϕT) of greater than 0.5 and a triplet lifetime (τT) of greater than 0.5 microseconds. Methods to prepare the rosin ester compositions and uses of the compositions are also disclosed.

  本公开涉及一种浅色或低色松香或松香酯组合物。松香酯包括一种或多种松香、一种或多种多元醇、可选的一种或多种单羧酸、可选的一种或多种具有 2 至 54 个碳原子的多羧酸的反应产物；0 ppm 至 200 ppm 的助催化剂、可选的歧化催化剂、酯化催化剂或它们的组合。助催化剂的三重态形成量子产率（ϕT）大于 0.5，三重态寿命（τT）大于 0.5 微秒。此外，还公开了松香酯组合物的制备方法和组合物的用途。

表征谱图