N-(9-ethylcarbazol-3-yl)-4-oxo-4-phenylbutanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(9-ethylcarbazol-3-yl)-4-oxo-4-phenylbutanamide
• 化学式: C₂₄H₂₂N₂O₂
• 分子量: 370.4
• InChiKey: XARYSXWTCPFVJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Carbazole derivatives for the treatment of NPY related diseases
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20040147752A1

  公开（公告）日：2004-07-29

  The invention relates to novel carbazole derivatives, their use for the preparation of a pharmaceutical composition for the treatment of eating and metabolic disorders such as obesity, bulimia nervosa, anorexia nervosa, of sleep disturbance, of morphine withdrawal symptoms and of epileptic seizures, a pharmaceutical composition containing them and a process for preparing them.

  本发明涉及新型咔唑衍生物，它们用于制备治疗饮食和代谢紊乱（如肥胖症、神经性贪食症、神经性厌食症）、睡眠障碍、吗啡戒断症状和癫痫发作的药物组合物，以及含有它们的药物组合物和制备它们的工艺。
• CARBAZOLE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NPY RELATED DISEASES
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP1395578A1

  公开（公告）日：2004-03-10
• [EN] CARBAZOLE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NPY RELATED DISEASES<br/>[FR] DERIVES DE CARBAZOLE ET LEUR UTILISATION POUR LA PREPARATION DE COMPOSITIONS PHARMACEUTIQUES DESTINEES AU TRAITEMENT DE MALADIES LIEES AU NEUROPEPTIDE Y (NPY)
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2002096902A1

  公开（公告）日：2002-12-05

  The invention relates to novel carbazole derivatives, their use for the preparation of a pharmaceutical composition for the treatment of eating and metabolic disorders such as obesity, bulimia nervosa, anorexia nervosa, of sleep disturbance, of morphine withdrawal symptoms and of epileptic seizures, a pharmaceutical composition containing them and a process for preparing them.
• [EN] HEPATITIS C VIRUS ENTRY INHIBITORS<br/>[FR] INHIBITEURS DE LA PÉNÉTRATION DU VIRUS DE L'HÉPATITE C
  申请人：IMMUSOL INC

  公开号：WO2008021745A2

  公开（公告）日：2008-02-21

  [EN] The present invention relates to the use of tricyclic diphenylamine derivative compounds for prevention and/or treatment of Hepatitis C virus (HCV) infection by inhibiting HCV entry into permissive cells.
  [FR] La présente invention concerne l'utilisation de composés dérivés de la diphénylamine tricyclique pour la prévention et/ou le traitement d'une infection par le virus de l'hépatite C (Hepatitis C Virus : HCV) en inhibant la pénétration du HCV dans les cellules permissives.