1,1,2-三氯-1,3-丁二烯 | 2852-07-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 中文名称: 1,1,2-三氯-1,3-丁二烯
• 英文名称: 1,1,2-trichlorobuta-1,3-diene
• 英文别名: 1,1,2-Trichlor-buta-1,3-dien；1,1,2-trichloro-1,3-butadiene；1,1,2-Trichlorbutadien；1,3-Butadiene, 1,1,2-trichloro-
• CAS: 2852-07-5
• 化学式: C₄H₃Cl₃
• 分子量: 157.427
• InChiKey: ZFBGKBGUMMBBMY-UHFFFAOYSA-N

物化性质

• 沸点：
  169.18°C (rough estimate)
• 密度：
  1.4060 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,1,2-三氯-1,3-丁二烯 以42%的产率得到
  参考文献：
  名称：

  TOGANYAN S. V.; BABAYAN V. O., AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH., 1979, 32, HO 1, 39-43

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯-丁-1-烯-3-炔 在 氯 作用下， 生成 1,1,2-三氯-1,3-丁二烯
  参考文献：
  名称：

  Shmatov,Yu.N. et al., Journal of Organic Chemistry USSR (English Translation), 1976, vol. 12, p. 297 - 306

  摘要：

  DOI：

文献信息

• Production of insecticidally active vinyl-cyclopropane carboxylic acid
  申请人：Bayer Aktiengesellschaft

  公开号：US04291176A1

  公开（公告）日：1981-09-22

  Insecticidally active vinyl-cyclopropane carboxylic acid esters of the formula ##STR1## are prepared by reacting ##STR2## in which R.sup.12 is a radical selected from the group consisting of ##STR3## with an alcoholate of the formula M--O--R.sup.8. Various processes for making the intermediates are also described. Many of the intermediates and end products are new.

  公式为##STR1##的杀虫活性乙烯-环丙烷羧酸酯可通过将##STR2##与R.sup.12为从##STR3##中选择的基团反应，与公式M--O--R.sup.8的醇酸盐反应制备而成。还描述了制备中间体的各种方法。许多中间体和最终产品都是新的。
• Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors
  作者：Ester Verdaguer、Elvira García-Jordà、Andrés Jiménez、Alessandra Stranges、Francesc X Sureda、Anna M Canudas、Elena Escubedo、Jordi Camarasa、Mercè Pallàs、Antoni Camins

  DOI：10.1038/sj.bjp.0704581

  日期：2002.3

  We examined the role of non‐NMDA receptors in kainic acid (KA)‐induced apoptosis in cultures of rat cerebellar granule cells (CGCs). KA (1 – 500 μM) induced cell death in a concentration‐dependent manner, which was prevented by NBQX and GYKI 52466, non‐NMDA receptor antagonists. Moreover, AMPA blocked KA‐induced excitotoxicity, through desensitization of AMPA receptors. Similarly, KA raised the intracellular calcium concentration of CGCs, which was inhibited by NBQX and GYKI 52466. Again, AMPA (100 μM) abolished the KA (100 μM)‐induced increase in intracellular calcium concentration. KA‐induced cell death in CGCs had apoptotic features, which were determined morphologically, by DNA fragmentation, and by expression of the prostate apoptosis response‐4 protein (Par‐4). KA (500 μM) slightly (18%) increased caspase‐3 activity, which was strongly enhanced by colchicine (1 μM), an apoptotic stimulus. However, neither Z‐VAD.fmk, a pan‐caspase inhibitor, nor the more specific caspase‐3 inhibitor, Ac‐DEVD‐CHO, prevented KA‐induced cell death or apoptosis. In contrast, both drugs inhibited colchicine‐induced apoptosis. The calpain inhibitor ALLN had no effect on KA or colchicine‐induced neurotoxicity. Our findings indicate that colchicine‐induced apoptosis in CGCs is mediated by caspase‐3 activation, unlike KA‐induced apoptosis. British Journal of Pharmacology (2002) 135, 1297–1307; doi:10.1038/sj.bjp.0704581

  我们研究了非NMDA受体在Kainic酸（KA）诱导的大鼠小脑颗粒细胞（CGCs）凋亡中的作用。 - KA（1–500 μM）以浓度依赖性方式诱导细胞死亡，这种作用被非NMDA受体拮抗剂NBQX和GYKI 52466所阻断。此外，AMPA通过使AMPA受体脱敏，阻止了KA诱导的兴奋性毒性。 - 类似地，KA升高了CGCs的胞内钙浓度，这种升高被NBQX和GYKI 52466抑制。此外，AMPA（100 μM）消除了KA（100 μM）引起的胞内钙浓度升高。 - KA诱导的CGCs凋亡具有典型的凋亡特征，包括形态学变化、DNA片段化以及前列腺凋亡反应蛋白-4（Par-4）的表达。 - KA（500 μM）轻微（18%）增加了Caspase-3的活性，而这种活性在加入秋水仙素（1 μM，一种凋亡刺激因子）后显著增强。然而，无论是广谱Caspase抑制剂Z-VAD.fmk，还是更特异的Caspase-3抑制剂Ac-DEVD-CHO，都无法阻止KA诱导的细胞死亡或凋亡。相反，这两种药物均抑制了秋水仙素诱导的凋亡。 - 胰蛋白酶抑制剂ALLN对KA或秋水仙素诱导的神经毒性无影响。 - 我们的发现表明，在CGCs中，秋水仙素诱导的凋亡是由Caspase-3活化介导的，而KA诱导的凋亡则不然。 ——《British Journal of Pharmacology》（2002）第135卷，1297–1307页； doi:[10.1038/sj.bjp.0704581](https://doi.org/10.1038/sj.bjp.0704581)
• Dehydration of halogenated, unsaturated alcohols to form halogenated,
  申请人：The Dow Chemical Company

  公开号：US04668832A1

  公开（公告）日：1987-05-26

  Halogenated, unsaturated alcohols are dehydrated by contacting the alcohol and a carrier gas with a silica alumina catalyst to form dienes of the formula: ##STR1## wherein each X is independently hydrogen, fluorine chlorine, or bromine with the proviso that no more than one of them is hydrogen, and each R is independently hydrogen, alkyl, aralkyl, alkaryl, or aryl.

  卤代不饱和醇通过与氧化硅铝催化剂接触，与载气一起脱水，形成式为：##STR1##其中每个X独立地为氢、氟、氯或溴，但不能超过一个为氢，每个R独立地为氢、烷基、芳基烷基、烷基芳基或芳基。
• A color photographic light-sensitive material
  申请人：KONICA CORPORATION

  公开号：EP0074763A1

  公开（公告）日：1983-03-23

  A color photographic light-sensitive material comprises a support and thereon a hydrophilic colloidal layer comprising a nondiffusible coupler and a hydrophilic colloidal layer comprising an aromatic primary amine developing agent and/or a precursor thereof. The color photographic light-sensitive material further comprises a polymer layer at the furthest position from the support on the same side of said hydrophilic colloidal layer, which polymer layer is permeable to an alkaline processing liquid but less permeable to said aromatic primary amine developing agent and/or precursor thereof.

  一种彩色感光照相材料，包括一个支座和其上的亲水胶体层，亲水胶体层包括不可扩散耦合剂和亲水胶体层，亲水胶体层包括芳香族伯胺显影剂和/或其前体。该彩色感光材料还包括一个聚合物层，位于所述亲水胶体层同一侧离支撑物最远的位置，该聚合物层可渗透碱性冲洗液，但对所述芳香族伯胺显影剂和/或其前体的渗透性较差。
• Adhesive composition,methods for the production and use thereof.
  申请人：LORD CORPORATION

  公开号：EP0321166A1

  公开（公告）日：1989-06-21

  An adhesive composition for bonding metal to natural or synthetic rubber, composed of a latex, an aromatic nitroso compound, and a polymaleimide compound. The adhesive composition may be formed by ballmilling the latex and the polymaleimide compound into a masterbatch of the aromatic nitroso compound. Bonded articles may be formed by applying the adhesive composition to a metal and contacting the metal surface with the rubber to effect bonding.

  一种用于将金属与天然或合成橡胶粘合的粘合剂组合物，由胶乳、芳香族亚硝基化合物和聚马来酰亚胺化合物组成。粘合剂组合物可通过将胶乳和聚马来酰亚胺化合物球磨成芳香族亚硝基化合物母料而形成。将粘合剂组合物涂在金属上，并使金属表面与橡胶接触以实现粘合，即可形成粘合物品。