2-[4-(1H-indol-3-yl)piperidin-1-yl]-4-pyridin-4-yl-1H-pyrimidin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[4-(1H-indol-3-yl)piperidin-1-yl]-4-pyridin-4-yl-1H-pyrimidin-6-one
• 化学式: C₂₂H₂₁N₅O
• 分子量: 371.4
• InChiKey: BSCPOGIFWJXHIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] 2-[NITROGEN-HETEROCYCLIC]PYRIMIDONE DERIVATIVES<br/>[FR] DERIVES DE LA 2-[AZOTE-HETEROCYCLIQUE]PYRIMIDONE
  申请人：SANOFI SYNTHELABO

  公开号：WO2001070728A1

  公开（公告）日：2001-09-27

  A pyrimidone derivative represented by formula (I) or a salt thereof wherein: R1 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or a halogen atom; (a) represents a [nitrogen-heterocyclic ring] of formula (X), (Y) or (Z). And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β such as Alzheimer's disease.