3-(quinolin-8-ylsulfonylamino)-3H-indole-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(quinolin-8-ylsulfonylamino)-3H-indole-2-carboxylic acid
• 化学式: C₁₈H₁₃N₃O₄S
• 分子量: 367.4
• InChiKey: JONRQZVEIMTKCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Indole derivatives as interleukin -4 gene expression inhibitors
  申请人：——

  公开号：US20040010029A1

  公开（公告）日：2004-01-15

  This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

  这项发明揭示并声明了一类新的吲哚衍生物，用于治疗过敏、哮喘、鼻炎、皮炎、B细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒（RSV）感染相关的疾病。现在已经发现，该发明的化合物能够调节T辅助细胞（Th）细胞、Th1 / Th2，从而能够抑制白细胞介素-4（IL-4）信息的转录、IL-4释放或IL-4的产生。
• 3-substituted amino-1H-indole-2-carboxylic acid and 3-substituted amino-benzo[B]thiophene-2carboxylic acid derivatives as interleukin-4 gene expression inhibitors
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1834947A2

  公开（公告）日：2007-09-19

  This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Thl/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

  本发明公开了一类新的吲哚衍生物，用于治疗过敏、哮喘、鼻炎、皮炎、B 细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒（RSV）感染有关的疾病。现已发现，本发明的化合物能够调节 T 辅助（Th）细胞 Thl/Th2，从而能够抑制白细胞介素-4（IL-4）信息的转录、IL-4 的释放或 IL-4 的产生。
• 3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1501796A1

  公开（公告）日：2005-02-02
• US7169925B2
  申请人：——

  公开号：US7169925B2

  公开（公告）日：2007-01-30
• [EN] 3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO' B! THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERIEUKIN-4 GENE EXPRESSION INHIBITORS<br/>[FR] ACIDE AMINO-1H-INDOLE-2-CARBOXYLIQUE 3-SUBSTITUE ET DERIVES D'ACIDE AMINO-BENZO' B! THIOPHENE-2-CARBOXYLIQUE SUBSTITUE UTILISES COMME INHIBITEURS D'EXPRESSION GENIQUE D'INTERLEUKINE 4
  申请人：AVENTIS PHARMA INC

  公开号：WO2003091215A1

  公开（公告）日：2003-11-06

  This inventions discloses and claims 3-substituted amino-1H-indole-2-carboxylic acid and 3-substituted amino-benzothiophene-2-carboxylic acid derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interieukin-4(IL-4) message, IL-4 release or IL-4 production.