Glp-D-Hph-Pro-NH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glp-D-Hph-Pro-NH2
• 英文别名: H-Pyr-D-hPhe-Pro-NH2；(2S)-N-[(2R)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxo-4-phenylbutan-2-yl]-5-oxopyrrolidine-2-carboxamide
• 化学式: C₂₀H₂₆N₄O₄
• 分子量: 386.451
• InChiKey: ZKGYSCIDBBYKKJ-XHSDSOJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Z-Glp-D-Hph-Pro-NH2 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以54%的产率得到Glp-D-Hph-Pro-NH2
  参考文献：
  名称：

  Synthesis of Analogues of Thyrotropin-Releasing Hormone

  摘要：

  The synthesis of ten new thyrotropin-releasing hormone analogues (15-24) which contain uncoded amino acids (L- and D-homoleucine, L- and D-homophenylalanine, L-homoproline and 6-ketopipecolic acid) is described here. The peptide bond formation was achieved in solution phase using pentafluorophenyl ester activation of the N-protected amino acids. The analogues were tested for their ability to release thyrotropin and for CNS activities and proved to be fully inactive.

  DOI：

  10.1002/prac.19943360609

文献信息

• Synthesis of Analogues of Thyrotropin-Releasing Hormone
  作者：Cs. Somlai、L. Bal�spiri

  DOI：10.1002/prac.19943360609

  日期：——

  The synthesis of ten new thyrotropin-releasing hormone analogues (15-24) which contain uncoded amino acids (L- and D-homoleucine, L- and D-homophenylalanine, L-homoproline and 6-ketopipecolic acid) is described here. The peptide bond formation was achieved in solution phase using pentafluorophenyl ester activation of the N-protected amino acids. The analogues were tested for their ability to release thyrotropin and for CNS activities and proved to be fully inactive.