H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-(βGlc)Ser-NH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-(βGlc)Ser-NH2
• 英文别名: <(βGlc)Ser⁷>dermorphin；[Ser⁷-O-βGlc]dermorphin；(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-amino-1-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropan-2-yl]pyrrolidine-2-carboxamide
• 化学式: C₄₆H₆₀N₈O₁₅
• 分子量: 965.027
• InChiKey: RTZVWSWPNYWXFJ-IIKLXXCXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  69
• 可旋转键数：
  22
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  375
• 氢给体数：
  13
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-[βGlc(Ac)4]Ser-NH2 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-(βGlc)Ser-NH2
  参考文献：
  名称：

  Dermorphin and Deltorphin Glycosylated Analogues:  Synthesis and Antinociceptive Activity after Systemic Administration

  摘要：

  In the present paper we describe the synthesis of some dermorphin and deltorphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.

  DOI：

  10.1021/jm9810699

文献信息

• Dermorphin and Deltorphin Glycosylated Analogues:  Synthesis and Antinociceptive Activity after Systemic Administration
  作者：Lucia Negri、Roberta Lattanzi、Fabio Tabacco、Luigi Orrù、Cinzia Severini、Barbara Scolaro、Raniero Rocchi

  DOI：10.1021/jm9810699

  日期：1999.2.1

  In the present paper we describe the synthesis of some dermorphin and deltorphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.