[1-(4-cyanophenyl)-2-(cyclopropylamino)-2-oxoethyl] 2-(1H-indol-3-yl)acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [1-(4-cyanophenyl)-2-(cyclopropylamino)-2-oxoethyl] 2-(1H-indol-3-yl)acetate
• 化学式: C₂₂H₁₉N₃O₃
• 分子量: 373.4
• InChiKey: QJWHIUZRTDRIED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  95
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ALPHA ACYLOXYACETAMIDES FOR KALLIKREIN AND UROKINASE INHIBITION<br/>[FR] ALPHA ACYLOXYACETAMIDES POUR L'INHIBITION DE LA KALLIKREINE ET DE L'UROKINASE
  申请人：GENZYME CORP

  公开号：WO2003101941A2

  公开（公告）日：2003-12-11

  Disclosed herein is a compound represented by Structural Formula (I). R1 is a substituted or unsubstituted aryl group or alkyl group; R2 is a substituted or unsubstituted aryl group or cycloalkyl group; Ar is a substituted or unsubstituted aryl group; X is a -CH2-, -O-, -S- or -CO-, m is an integer from zero to two; n is an integer from 0-2 when X is -O-, -S- and 1-2 when X is -CH2- or -CO-. Also disclosed are methods of inhibiting kallikrein activity or urokinase activity in subject in need of such inhibition by administering a compound represented by Structural Formula (I).