1,2,3-三[顺式-9-十六基]甘油 | 20246-55-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 1,2,3-三[顺式-9-十六基]甘油
• 中文别名: 三棕榈油酸甘油酯
• 英文名称: Tripalmitolein
• 英文别名: 2,3-bis[[(Z)-hexadec-9-enoyl]oxy]propyl (Z)-hexadec-9-enoate
• CAS: 20246-55-3；30773-83-2
• 化学式: C₅₁H₉₂O₆
• 分子量: 801.3
• InChiKey: SKGWNZXOCSYJQL-BUTYCLJRSA-N

物化性质

• 沸点：
  765.9±50.0 °C(Predicted)
• 密度：
  0.929±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿：可溶
• LogP：
  20.387 (est)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  19.1
• 重原子数：
  57
• 可旋转键数：
  47
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 海关编码：
  2916190090

反应信息

• 作为反应物：
  描述：

  1,2,3-三[顺式-9-十六基]甘油 、 水 生成 Palmitoleate 、 1,3-Dipalmitoleoylglycerol 、 氢(+1)阳离子
  参考文献：
  名称：

  Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases

  摘要：

  Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids. DAG exists in three stereochemical isoforms. Here we show that ATGL exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone. The selectivity of ATGL broadens to the sn-1 position upon stimulation of the enzyme by its co-activator CGI-58. sn-1,3 DAG is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase. Interestingly, diacylglycerol-O-acyltransferase 2, present at the endoplasmic reticulum and on lipid droplets, preferentially esterifies sn-1,3 DAG. This suggests that ATGL and diacylglycerol-O-acyltransferase 2 act coordinately in the hydrolysis/re-esterification cycle of TAGs on lipid droplets. Because ATGL preferentially generates sn-1,3 and sn-2,3, it suggests that TAG-derived DAG cannot directly enter phospholipid synthesis or activate protein kinase C without prior isomerization.

  DOI：

  10.1074/jbc.m112.400416

文献信息

• Mutant of Geotrichum candidum which produces novel enzyme system to
  申请人：Henkel Corporation

  公开号：US05470741A1

  公开（公告）日：1995-11-28

  A mutant fungal strain, namely G. candidum NRRL Y-552, mutant known as Henkel 9-2-3-9 (ATCC 74170) produces a lipase called "UNLipase" providing a selectivity of 25:1 for oleic acid over palmitic acid by the assay procedure employed. UNLipase has a temperature range of operation of between 0 and 40 degrees Celsius (and no activity over 55 degrees Celsius). The optimum pH ranges are between 7.5 and 8.5. Magnesium cations increase activity, whereas calcium cations are inhibitory. The molecular weight of the protein appears to be 65 kDa by size exclusion chromatography. UNLipase shows a high degree of selectivity for hydrolysis, esterification and transesterification.

  一种突变真菌菌株，名为G. candidum NRRL Y-552，突变体称为Henkel 9-2-3-9（ATCC 74170），产生一种称为“UNLipase”的脂肪酶，通过所采用的测定程序，提供油酸对棕榈酸的选择性为25：1。UNLipase的操作温度范围在0至40摄氏度之间（55摄氏度以上无活性）。最适pH范围在7.5至8.5之间。镁阳离子增加活性，而钙阳离子具有抑制作用。通过分子量排除色谱法，蛋白质的分子量似乎为65 kDa。UNLipase表现出高度的水解、酯化和转酯化选择性。
• Mutant of geotrichum candidum which produces novel enzyme system to
  申请人：Henkel Corporation

  公开号：US05726048A1

  公开（公告）日：1998-03-10

  A mutant fungal strain, namely G. candidum NRRL Y-552, mutant known as Henkel 9-2-3-9 produces a lipase called "UNLipase" providing a selectivity of 25:1 for oleic acid over palmitic acid by the assay procedure employed. UNLipase has a temperature range of operation of between 0 and 40 degrees Celsius (and no activity over 55 degrees Celsius). The optimum pH ranges are between 7.5 and 8.5. Magnesium cations increase activity, whereas calcium cations are inhibitory. The molecular weight of the protein appears to be 65 kDa by size exclusion chromatography. UNLipase shows a high degree of selectivity for hydrolysis, esterification and transesterification.

  一种突变的真菌菌株，即G. candidum NRRL Y-552，突变体被称为Henkel 9-2-3-9，产生一种名为“UNLipase”的脂肪酶，通过所采用的测定程序，提供了25:1的油酸选择性，超过棕榈酸。 UNLipase的操作温度范围为0至40摄氏度（55摄氏度以上无活性）。最适pH范围在7.5至8.5之间。镁阳离子可以增加活性，而钙阳离子则具有抑制作用。根据尺寸排除色谱法，该蛋白质的分子量似乎为65 kDa。UNLipase对水解、酯化和转酯化表现出高度的选择性。
• Treatment of hair by addition of exogenous enzymes, alcohols and acids or triglycerides
  申请人：——

  公开号：US20030091526A1

  公开（公告）日：2003-05-15

  The present invention relates to compositions for treating keratin materials by adding at least one exogenous enzyme, long-chain alcohols, and long-chain acids or triglycerides, which gives rise to an enzymatic reaction directly on the hair, and to methods of treating hair which employ these compositions.

  本发明涉及通过添加至少一种外源酶、长链醇和长链酸或甘油三酯来处理角蛋白材料的组合物，这种组合物会直接在头发上产生酶反应，本发明还涉及使用这些组合物处理头发的方法。
• OPHTHALMIC FLUID
  申请人：Planned Products PTY Ltd.

  公开号：EP1214068B1

  公开（公告）日：2006-10-18
• Method and System For the Selective Oxidative Decarboxylation of Fatty Acids
  申请人：Holmes Bryan J.

  公开号：US20120209049A1

  公开（公告）日：2012-08-16

  Selective, radically initiated oxidative decarboxylation may produce low viscosity renewable fuels from biologically derived fats and oils. Fatty acids and triglycerides may be decarboxylated using oxidants at a water/oil interface. The oxidants may be produced using photo-Fenton reagents. The reaction advantageously can be carried out at room temperature and pressure and has fewer unwanted byproducts than traditional decarboxylation techniques.