1,2,3-噻二唑-5-甲酰肼 | 80407-71-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,2,3-噻二唑-5-甲酰肼
• 英文名称: Lysine butyrate
• 英文别名: butanoic acid;(2S)-2,6-diaminohexanoic acid
• CAS: 80407-71-2
• 化学式: C10H22N2O4
• 分子量: 234.29
• InChiKey: RAQUISHGVNOAMH-JEDNCBNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Antiprotozoal methods, compositions and feedstuffs
  申请人：UNIVERSITEIT GENT

  公开号：EP1234508A1

  公开（公告）日：2002-08-28

  Methods and compositions for the prophylactic treatment of coccidiosis and other protozoal infections are described. Preferably, these are administered in the drinking water of the animals, e.g. in the drinking water of poultry to provide a mass prophylactic treatment. These formulations include L-arginine and may also include a modulator of the NO biosynthesis pathway, e.g. and NSAID such as Ibuprofen. These formulations have also been found to improve egg production in hens.

  本文介绍了预防性治疗球虫病和其他原生动物感染的方法和组合物。最好是在动物的饮用水中，例如在家禽的饮用水中施用，以提供大规模的预防性治疗。 这些制剂包括 L-精氨酸，还可能包括 NO 生物合成途径的调节剂，例如非甾体抗炎药，如布洛芬。 研究还发现，这些制剂可提高母鸡的产蛋量。
• Hepatocyte lineage cells derived from pluripotent stem cells
  申请人：GERON CORPORATION

  公开号：EP2256187A1

  公开（公告）日：2010-12-01

  It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example, human embryonic stem cells are allowed to form embryoid bodies, and then combined with the differentiation agent n-butyrate, optionally supplemented with maturation factors. In another example, n-butyrate is added to human embryonic stem cells in feeder-free culture. Either way, a remarkably uniform cell population is obtained, which is predominated by cells with morphological features of hepatocytes, expressing surface markers characteristic of hepatocytes, and having enzymatic and biosynthetic activity important for liver function.; Since stem cells readily proliferate in culture, this system provides an abundant source of cells of the hepatocyte lineage for a variety of applications, such as drug screening, and replenishing liver function in the context of clinical treatment.

  人们发现，当多能干细胞在肝细胞分化剂存在下进行培养时，会产生一种细胞群体，其中具有肝细胞表型特征的细胞比例非常高。在一个例子中，让人类胚胎干细胞形成类胚体，然后与分化剂正丁酸盐结合，可选择补充成熟因子。在另一个例子中，将正丁酸加入无饲养者培养的人类胚胎干细胞中。无论采用哪种方法，都能获得非常均匀的细胞群，其中主要是具有肝细胞形态特征的细胞，表达肝细胞特有的表面标志物，并具有对肝功能非常重要的酶和生物合成活性；由于干细胞在培养过程中容易增殖，该系统为各种应用提供了丰富的肝细胞系细胞来源，如药物筛选和在临床治疗中补充肝功能。
• Process for making hepatocytes from pluripotent stem cells
  申请人：——

  公开号：US20020160511A1

  公开（公告）日：2002-10-31

  It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example, human embryonic stem cells are allowed to form embryoid bodies, and then combined with the differentiation agent n-butyrate, optionally supplemented with maturation factors. In another example, n-butyrate is added to human embryonic stem cells in feeder-free culture. Either way, a remarkably uniform cell population is obtained, which is predominated by cells with morphological features of hepatocytes, expressing surface markers characteristic of hepatocytes, and having enzymatic and biosynthetic activity important for liver function. Since stem cells readily proliferate in culture, this system provides an abundant source of cells of the hepatocyte lineage for a variety of applications, such as drug screening, and replenishing liver function in the context of clinical treatment.

  人们发现，当多能干细胞在肝细胞分化剂存在下进行培养时，会产生一种细胞群体，其中具有肝细胞表型特征的细胞比例非常高。在一个例子中，让人类胚胎干细胞形成类胚体，然后与分化剂正丁酸盐结合，可选择补充成熟因子。在另一个例子中，将正丁酸加入无饲养者培养的人类胚胎干细胞中。无论采用哪种方法，都能获得非常均匀的细胞群，其中主要是具有肝细胞形态特征的细胞，表达肝细胞特有的表面标记，并具有对肝功能很重要的酶和生物合成活性。由于干细胞在培养过程中容易增殖，该系统提供了丰富的肝细胞系细胞来源，可用于药物筛选和临床治疗中的肝功能补充等多种应用。
• Hepatocytes for therapy and drug screening made from embryonic stem cells
  申请人：——

  公开号：US20030003573A1

  公开（公告）日：2003-01-02

  It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example, human embryonic stem cells are allowed to form embryoid bodies, and then combined with the differentiation agent n-butyrate, optionally supplemented with maturation factors. In another example, n-butyrate is added to human embryonic stem cells in feeder-free culture. Either way, a remarkably uniform cell population is obtained, which is predominated by cells with morphological features of hepatocytes, expressing surface markers characteristic of hepatocytes, and having enzymatic and biosynthetic activity important for liver function. Since stem cells readily proliferate in culture, this system provides an abundant source of cells of the hepatocyte lineage for a variety of applications, such as drug screening, and replenishing liver function in the context of clinical treatment.

  人们发现，当多能干细胞在肝细胞分化剂存在下进行培养时，会产生一种细胞群体，其中具有肝细胞表型特征的细胞比例非常高。在一个例子中，让人类胚胎干细胞形成类胚体，然后与分化剂正丁酸盐结合，可选择补充成熟因子。在另一个例子中，将正丁酸加入无饲养者培养的人类胚胎干细胞中。无论采用哪种方法，都能获得非常均匀的细胞群，其中主要是具有肝细胞形态特征的细胞，表达肝细胞特有的表面标记，并具有对肝功能很重要的酶和生物合成活性。由于干细胞在培养过程中容易增殖，该系统提供了丰富的肝细胞系细胞来源，可用于药物筛选和临床治疗中的肝功能补充等多种应用。
• Methods and compositions for immunomodulation using CD1 antigens
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20040265976A1

  公开（公告）日：2004-12-30

  The invention relates to novel CD1a-presented antigens. These antigens can be used as antigens, adjuvants or as immunomodulatory agents in a variety of diagnostic, therapeutic and prophylactic applications.

  本发明涉及新型 CD1a 呈递抗原。这些抗原可用作抗原、佐剂或免疫调节剂，用于各种诊断、治疗和预防。