1,2-二(十六烷氧基)-3-三甲基氨基丙烷 | 921-28-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 1,2-二(十六烷氧基)-3-三甲基氨基丙烷
• 英文名称: beta-Isopropylmalate
• 英文别名: (2S,3S)-2-hydroxy-3-propan-2-ylbutanedioic acid
• CAS: 921-28-8
• 化学式: C₇H₁₂O₅
• 分子量: 176.17
• InChiKey: RNQHMTFBUSSBJQ-WHFBIAKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Mutated isopropylmalate isomerase
  申请人：Ikeda Masato

  公开号：US20050130276A1

  公开（公告）日：2005-06-16

  The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform bacterium which produces the polypeptide comprising the amino acid sequence as the sole isopropylmalate isomerase exhibits a partial leucine requirement in a minimal medium; a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism transformed with the recombinant DNA, and a process for producing an L-amino acid using the microorganism.

  本发明提供了一个多肽，其包括从属于Coryneform细菌的微生物中获得的异丙基丙酸异构酶的氨基酸序列中至少删除，替换或添加了至少一个氨基酸，其中生产包含该氨基酸序列作为唯一异丙基丙酸异构酶的Coryneform细菌在最小培养基中表现出部分亮氨酸需求；编码该多肽的DNA，包含该DNA的重组DNA，转化了重组DNA的微生物以及使用该微生物生产L-氨基酸的方法。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Microorganism having enhanced L-valine productivity and method for producing L-valine using the same
  申请人：CJ CheilJedang Corporation

  公开号：EP2559753A1

  公开（公告）日：2013-02-20

  The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a Corynebacterium glutamicum mutant strain that has resistance to L-valine and derivatives thereof so as to have an enhanced L-valine productivity, and a method for producing L-valine using the same.

  本发明涉及一种具有增强的 L-缬氨酸生产率的微生物，以及使用该微生物生产 L-缬氨酸的方法。更具体地说，本发明涉及一种对 L-缬氨酸及其衍生物具有抗性的谷氨酸棒状杆菌突变菌株，从而具有更高的 L-缬氨酸生产率，以及使用该菌株生产 L-缬氨酸的方法。
• STRAIN HAVING ENHANCED L-VALINE PRODUCTIVITY AND L-VALINE PRODUCTION METHOD USING THE SAME
  申请人：Cj Cheiljedang Corporation

  公开号：EP2975114A1

  公开（公告）日：2016-01-20

  The present invention relates to a novel L-valine-producing strain which is transformed so as to strengthen the expression of L-valine operon by having a nucleotide sequence, for coding a leader peptide in a regulatory region of ilvBN operon, entirely deleted, or partially deleted or substituted. In addition, the present invention relates to a method for producing L-valine using the novel L-valine-producing strain. According to the novel valine-producing strain and the L-valine production method of the present invention using the strain, there is an advantageous effect of producing L-valine at high efficiency and high yield.

  本发明涉及一种新型 L-缬氨酸生产菌株，该菌株通过完全删除或部分删除或替换 ilvBN 操作子调控区中用于编码领导肽的核苷酸序列，进行转化以加强 L-缬氨酸操作子的表达。此外，本发明还涉及一种使用新型 L-缬氨酸生产菌株生产 L-缬氨酸的方法。根据本发明的新型缬氨酸生产菌株和使用该菌株的 L-缬氨酸生产方法，具有高效率和高产率生产 L-缬氨酸的优势效果。
• MICROORGANISM HAVING L-LEUCINE PRODUCTIVITY, AND METHOD FOR PREPARING L-LEUCINE USING SAME
  申请人：CJ Cheiljedang Corporation

  公开号：EP3342871A1

  公开（公告）日：2018-07-04

  The present disclosure relates to a microorganism producing L-leucine and a method for producing L-leucine using the same, and more specifically, to a Corynebacterium glutamicum mutant which has resistance to L-leucine and a derivative thereof and improved L-leucine producing ablility, and a method for producing L-leucine using the same.

  本公开涉及一种生产 L-亮氨酸的微生物和使用该微生物生产 L-亮氨酸的方法，更具体地说，涉及一种对 L-亮氨酸及其衍生物具有抗性和改进的 L-亮氨酸生产能力的谷氨酸棒状杆菌突变体，以及使用该突变体生产 L-亮氨酸的方法。