1,2-二甲基-4,5,6,7-四氢吲哚 | 62372-19-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 1,2-二甲基-4,5,6,7-四氢吲哚
• 英文名称: 1,2-Dimethyl-4,5,6,7-tetrahydro-indol
• 英文别名: 1,2-dimethyl-4,5,6,7-tetrahydro-indole；1H-Indole, 4,5,6,7-tetrahydro-1,2-dimethyl-；1,2-dimethyl-4,5,6,7-tetrahydroindole
• CAS: 62372-19-4
• 化学式: C₁₀H₁₅N
• 分子量: 149.236
• InChiKey: ROHJWBQWTCRCFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  N-cyclohexylidenemethylamine 以 乙腈 为溶剂， 反应 15.0h， 生成 1,2-二甲基-4,5,6,7-四氢吲哚
  参考文献：
  名称：

  Pyrrol-Anellierung von Ketonen durch Addition deprotonierter Imine an 2,-(N-Methylanilino)-acrylonitrile

  摘要：

  DOI：

  10.1055/s-1984-30914

文献信息

• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2016055028A1

  公开（公告）日：2016-04-14

  The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

  本发明涉及式(I)的化合物及其盐，其中A具有规范中定义的任何值，以及其组合物和用途。这些化合物可用作CBP和/或EP300的抑制剂。还包括包含式(I)的化合物或其药学上可接受的盐的药物组合物，以及在治疗各种CBP和/或EP300介导的疾病中使用这些化合物和盐的方法。
• Heterocyclic compound and use thereof
  申请人：Takanobu Kuroita

  公开号：US20100137587A1

  公开（公告）日：2010-06-03

  Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

  由以下公式表示的化合物，其中每个符号如规范中定义，并且其前药具有优越的肾素抑制活性，可用作预防或治疗高血压、高血压引起的各种器官损伤等药物。
• The thermal rearrangement of N-alkyl-N-vinylpropargylamines into 2-methylpyrroles. A new synthesis of annulated[b]pyrroles
  作者：J. Cossy、C. Poitevin、L. Sallé、D. Gomez Pardo

  DOI：10.1016/s0040-4039(96)01467-0

  日期：1996.9

  The thermolysis of N-alkyl-N-vinylpropargylamines produced annulated[b]pyrroles with moderate to good yields. The formation of these substituted pyrroles probably involves a tandem aza-Claisen rearrangement-cyclization reaction.

  N-烷基-N-乙烯基炔丙基胺的热解产生环化的[ b ]吡咯，产率中等至良好。这些取代的吡咯的形成可能涉及串联的氮杂-克莱森重排-环化反应。
• HETEROCYCLIC COMPOUND AND USE THEREOF
  申请人：Kuroita Takanobu

  公开号：US20110178057A1

  公开（公告）日：2011-07-21

  Compounds represented by the formulas (I) (II) wherein each symbol is as defined in the specification, and a pro-drug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

  由公式（I）（II）所代表的化合物，其中每个符号如规范中所定义，并且其前药具有优越的肾素抑制活性，并且可用作预防或治疗高血压、由高血压引起的各种器官损伤等的药物。
• ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF
  申请人：BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD.

  公开号：US20220393115A1

  公开（公告）日：2022-12-08

  Provided are an organic electroluminescent material and a device thereof. The organic electroluminescent material is a metal complex comprising a ligand L a having a structure of Formula 1. The metal complex may be used as a light-emitting material in an electroluminescent device. These novel compounds may be applied to electroluminescent devices and can exhibit better performance, achieve higher device efficiency, and significantly improve the overall performance of the devices. Further provided are an electroluminescent device comprising the metal complex and a compound combination comprising the metal complex.

  提供一种有机电致发光材料及其器件。该有机电致发光材料是一种金属配合物，包括一种具有式1结构的配体L。该金属配合物可用作电致发光器件的发光材料。这些新型化合物可应用于电致发光器件，并能展现更好的性能，实现更高的器件效率，并显著提高器件的整体性能。还提供了包括该金属配合物和一种化合物组合的电致发光器件。

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