1,2-二肉豆蔻酰-RAC-甘油-3-甲氧基聚乙二醇2000 | 160743-62-4

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 1,2-二肉豆蔻酰-RAC-甘油-3-甲氧基聚乙二醇2000
• 英文名称: mPEG-Dimyristoyl glycerol
• 英文别名: [3-(2-methoxyethoxy)-2-tetradecanoyloxypropyl] tetradecanoate
• CAS: 160743-62-4
• 化学式: C₃₄H₆₆O₆
• 分子量: 570.9
• InChiKey: HYXWVUFYXOOASK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.3
• 重原子数：
  40
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HPV VACCINE
  申请人：Merck Sharp & Dohme LLC

  公开号：EP4103227A1

  公开（公告）日：2022-12-21
• MEANS FOR LUNG SPECIFIC DELIVERY
  申请人：SILENCE THERAPEUTICS GMBH

  公开号：US20160303047A1

  公开（公告）日：2016-10-20

  The present invention is related to composition comprising a lipid composition, wherein the lipid composition consists of a cationic lipid of formula (I) wherein n is any one of 1, 2, 3, and 4, wherein m is any one of 1, 2 and 3, Y′ is an anion, wherein each of R1 and R2 is individually and independently selected from the group consisting of linear C12-C18 alkyl and linear C12-C18 alkenyl; a sterol compound, wherein the sterol compound is selected from the group consisting of cholesterol and stigmasterol; and a PEGylated lipid, wherein the PEGylated lipid comprises a PEG moiety and wherein the PEGylated lipid is selected from the group consisting of a PEGylated phosphoethanolamine of formula (II) wherein each of R3 and R4 is individually and independently linear C13-C17 alkyl, and p is any integer from 15 to 130; a PEGylated ceramide of formula (III) wherein R5 is linear C7-C15 alkyl, and q is any integer from 15 to 130; and a PEGylated diacylglycerol of formula (IV) wherein each of R6 and R7 is individually and independently linear C11-C17 alkyl, and r is any integer from 15 to 130.
• [EN] HPV VACCINE<br/>[FR] VACCIN ANTI-HPV
  申请人：MERCK SHARP & DOHME

  公开号：WO2021163002A1

  公开（公告）日：2021-08-19

  The present disclosure provides, among other things, a pharmaceutical composition that includes a lipid nanoparticle adjuvant and an anti-human papillomavirus (HPV) comprising HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.