STUDIES ON METAB OF PRONAMIDE IN RAT & COW HAVE BEEN REPORTED. ...NO DIRECT EVIDENCE WAS PRESENTED TO INDICATE CLEAVAGE OF AMIDE LINKAGE OR AN ALTERATION OF 3,5-DICHLOROPHENYL RING. THUS, PRONAMIDE APPEARS TO BE DEGRADED IN ANIMALS TO NUMBER OF PRODUCTS SIMILAR TO THOSE REPORTED IN PLANTS & SOIL.
AFTER ADMIN ... /PRONAMIDE/ TO RATS & COWS PER ORAL /ROUTE/ UNCHANGED /PRONAMIDE ACCOUNTED FOR ONE-HALF OF THAT PROPORTION OF THE DOSE EXCRETED IN THE FECES, BUT FOR VERY LITTLE IN THE URINE. THE PRINCIPAL METABOLITES IN FECES OF TREATED RATS WERE 2-(3,5-DICHLOROPHENYL)-4,4-DIMETHYL-5-METHYLENEOXAZOLINE (535), N-(1,1-DIMETHYLACETONYL)-3,5-DICHLOROBENZAMIDE (536), 2-(3,5-DICHLOROPHENYL)-4,4-DIMETHYL-5-HYDROXYMETHYLOXAZOLINE (537), N-(1,1-DIMETHYL-3-HYDROXYACETONYL)-3,5-DICHLOROBENZAMIDE (538), N-(1,1-DIMETHYL-3-HYDROXYPROPYL)-3,5-DICHLOROBENZAMIDE (539), N-(1,1-DIMETHYL-2,3-DIHYDROXYPROPYL)-3,5-DICHLOROBENZAMIDE (540), BETA-(3,5-DICHLOROBENZAMIDO)-BETA-METHYLBUTYRIC ACID (541), & ALPHA-(3,5-DICHLOROBENZAMIDO)ISOBUTYRIC ACID (542), & IN RAT URINE THEY WERE (537), (538), (540), (541), (542), & BETA-(3,5-DICHLOROBENZAMIDO)-ALPHA-HYDROXY-BETA-METHYLBUTYRIC ACID (543). IN THE URINE OF TREATED COWS (541), (542), & (543) WERE PRESENT. A TENTATIVE INTER-RELATIONSHIP AMONG THE VARIOUS METABOLITES IS ILLUSTRATED.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
癌症分类：B2组可能的人类致癌物
Cancer Classification: Group B2 Probable Human Carcinogen
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌物分类
对人类不具有致癌性（未被国际癌症研究机构IARC列名）。
No indication of carcinogenicity to humans (not listed by IARC).
Propyzamide is pratically non-toxic to mammals on an acute oral exposure basis., however a 2-generation reproduction study in rats found that propyzamide caused effects on both adult and offspring body size.
来源:Toxin and Toxin Target Database (T3DB)
毒理性
症状
Propyzamide在涂抹于皮肤上时会引起局部刺激。
Propyzamide causes local irritation when applied to the skin.
来源:Toxin and Toxin Target Database (T3DB)
毒理性
副作用
职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
TRACES OF THE PARENT HERBICIDE WERE FOUND IN MILK OF COWS TREATED WITH 5 PPM OF KERB (N-(1,1-DIMETHYLPROPYNYL)-3,5-DICHLOROBENZAMIDE) IN THE FEED, BUT NONE OF THE KNOWN METABOLITES WERE FOUND.
To obtain activity, pronamide must move into the root zone of the weeds. Little activity is obtained from foliar contact alone. Pronamide is readily absorbed by plants through the root system, translocated upward, and distributed into the entire plant. The degree of translocation from leaf absorption is not appreciable.
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
从大鼠和牛的胃肠道吸收不良；通过侧链氧化代谢，并随尿液和粪便排出。
Poorly absorbed from the gastrointestinal tract of rats and cows; metabolized by side-chain oxidation and excreted in urine and feces.
A simple high pressure liquid chromatography procedure was used to determine pronamide exposure in sprayers and their dermal absorption and excretion in guinea pigs. Results of dermal application to guinea pigs demonstrated a strong correlation between the applied dermal dose and the urinary residue excretion over the dosage range tested. As the dosage was increased the urinary excretion of residues was also increased. Residue levels were also determined to estimate skin contamination after sampling by filter pads attached to the clothing and arms of agricultural sprayers. Residues in the workers urine before and after exposure were also determined. Average exposure values of 0.83 mg/hr/person for pronamide were extrapolated from residue values obtained from analyzing the pads. Little correlation was found between the measured residues from exposed subjects and residues quantified in their urine samples.
[EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
申请人：GILEAD APOLLO LLC
公开号：WO2017075056A1
公开（公告）日：2017-05-04
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
[EN] 3-[(HYDRAZONO)METHYL]-N-(TETRAZOL-5-YL)-BENZAMIDE AND 3-[(HYDRAZONO)METHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE DERIVATIVES AS HERBICIDES<br/>[FR] DÉRIVÉS DE 3-[(HYDRAZONO))MÉTHYL]-N-(TÉTRAZOL-5-YL)-BENZAMIDE ET DE 3-[(HYDRAZONO)MÉTHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE UTILISÉS EN TANT QU'HERBICIDES
申请人：SYNGENTA CROP PROTECTION AG
公开号：WO2021013969A1
公开（公告）日：2021-01-28
The present invention related to compounds of Formula (I): or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4, R5 and R6 are as described herein. The invention further relates to compositions comprising said compounds, to methods of controlling weeds using said compositions, and to the use of compounds of Formula (I) as a herbicide.
[EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
申请人：SYNGENTA PARTICIPATIONS AG
公开号：WO2013079350A1
公开（公告）日：2013-06-06
Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.
式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
[EN] HERBICIDALLY ACTIVE HETEROARYL-S?BSTIT?TED CYCLIC DIONES OR DERIVATIVES THEREOF<br/>[FR] DIONES CYCLIQUES SUBSTITUÉES PAR HÉTÉROARYLE À ACTIVITÉ HERBICIDE OU DÉRIVÉS DE CELLES-CI
申请人：SYNGENTA LTD
公开号：WO2011012862A1
公开（公告）日：2011-02-03
The invention relates to a compound of formula (I), which is suitable for use as a herbicide wherein G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or latentiating group; Q is a unsubstituted or substituted C3-C8 saturated or mono-unsaturated heterocyclyl containing at least one heteroatom selected from O, N and S, or Q is heteroaryl or substituted heteroaryl; m is 1, 2 or 3; and Het is an optionally substituted monocyclic or bicyclic heteroaromatic ring; and wherein the compound is optionally an agronomically acceptable salt thereof.
The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
