1,3,5-三氮杂螺[5.5]十一碳-1,3-二烯-2,4-二胺 | 76766-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 1,3,5-三氮杂螺[5.5]十一碳-1,3-二烯-2,4-二胺
• 英文名称: 1,3,5-Triazaspiro<5.5>undeca-1,3-dien-2,4-diamin
• 英文别名: 1,3,5-Triazaspiro[5.5]undeca-1,3-diene-2,4-diamine；1,3,5-triazaspiro[5.5]undeca-1,4-diene-2,4-diamine
• CAS: 76766-46-6
• 化学式: C₈H₁₅N₅
• 分子量: 181.241
• InChiKey: CRKFVFNBXQJZJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己酮 、 胍 反应 48.0h， 生成 1,3,5-三氮杂螺[5.5]十一碳-1,3-二烯-2,4-二胺
  参考文献：
  名称：

  �ber substituierte 1,6-Dihydro-1,3,5-triazin-2,4-diamine, 1?,5?,6?,7?-Tetrahydrospiro[cyclopentan-1,4?-cyclopentapyrimidin]-2?(3? H)-imine und das 6-Phenyl-2,4-pyrimidindiamin

  摘要：

  DOI：

  10.1007/bf00909677

文献信息

• WENDELIN W.; ZMOELNIG I.; SCHRAMM H.-W., MONATSH. CHEM., 1980, 111, NO 5, 1189-1202
  作者：WENDELIN W.、 ZMOELNIG I.、 SCHRAMM H.-W.

  DOI：——

  日期：——
• Chemical Inhibitors of Inhibitors of Differentiation
  申请人：CHAUDHARY Jaideep

  公开号：US20090226422A1

  公开（公告）日：2009-09-10

  The present invention provides identification of inhibitors of inhibitors of differentiation (Id) for use in the treatment and prevention of diseases in mammals. The inhibitors of Id are effective alone in the treatment of a variety of cellular proliferative disorders including, but not limited to, diseases such as cancer, arthritis, age-related macular degeneration, psoriasis, neoplasms, angiomas, endometriosis, obesity, age-related macular degeneration, retinopathies, restenosis, scaring, fibrogenesis, fibrosis, cardiac remodeling, pulmonary fibrosis, scleroderma, failure associated with myocardial infarction, keloids, fibroid tumors and stenting. Additionally, these compounds are effective in blocking angiogenesis in tumor development, inducing apoptosis in malignant cells, inhibiting proliferation of cancer cells, increasing the effectiveness of chemotherapeutic agents, regulating transcriptional activity, reducing inflammation, increasing cellular differentiation, modulating ETS domain transcription factors, modulating PAX transcription factors, modulating TCF-ETS domain transcription factors, down regulating RAF-1/MAPK, upregulating JNK signaling pathways, and modulating cellular transformation.
• US8138356B2
  申请人：——

  公开号：US8138356B2

  公开（公告）日：2012-03-20
• �ber substituierte 1,6-Dihydro-1,3,5-triazin-2,4-diamine, 1?,5?,6?,7?-Tetrahydrospiro[cyclopentan-1,4?-cyclopentapyrimidin]-2?(3? H)-imine und das 6-Phenyl-2,4-pyrimidindiamin
  作者：Winfried Wendelin、Ilse Zm�lnig、Hans-Wolfgang Schramm

  DOI：10.1007/bf00909677

  日期：——