1,4-二乙酰氧基-2-甲基-丁烷 | 51814-03-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,4-二乙酰氧基-2-甲基-丁烷
• 英文名称: 1,4-diacetoxy-2-methyl-butane
• 英文别名: 1,4-Diacetoxy-2-methyl-butan；(4-Acetyloxy-3-methylbutyl) acetate
• CAS: 51814-03-0
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: BHMHFYWLBXKFJE-UHFFFAOYSA-N

物化性质

• 沸点：
  110 °C(Press: 13 Torr)
• 密度：
  1.020±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二溴-2-甲基丁烷 生成 1,4-二乙酰氧基-2-甲基-丁烷
  参考文献：
  名称：

  Faworsdi, Justus Liebigs Annalen der Chemie, 1907, vol. 354, p. 362

  摘要：

  DOI：

文献信息

• Studies on the enantioselectivity of the transesterification of 2-methyl-1,4-butanediol and its derivatives catalyzed by Pseudomonas fluorescens lipase in organic solvents
  作者：Paride Grisenti、Patrizia Ferraboschi、Silvana Casati、Enzo Santaniello

  DOI：10.1016/s0957-4166(00)80144-5

  日期：1993.5

  The irreversible transesterification of 2-methyl-1,4-butanediol 1a and its benzyl ethers 2a and 3a catalyzed by Pseudomonas fluorescens lipase in chloroform was studied, the highest ee (>98%) having been obtained for the 4-benzyl ether 2a.

  研究了荧光假单胞菌脂肪酶在氯仿中催化的2-甲基-1,4-丁二醇1a及其苄基醚2a和3a的不可逆酯交换反应，对于4-苄基醚2a已获得最高ee（> 98％）。
• Sulfamic acid as a cost-effective catalyst instead of metal-containing acids for acetolysis of cyclic ethers
  作者：Bo Wang、Yanlong Gu、Weizhong Gong、Yuru Kang、Liming Yang、Jishuan Suo

  DOI：10.1016/j.tetlet.2004.07.024

  日期：2004.8

  Sulfamic acid has been used as an efficient catalyst and green alternative for meta 1-containing acidic materials to promote the acetolysis reaction of THF to produce 1,4-diacetoxybutane. This method is also applicable to the acetolysis of other cyclic ethers, such as methyl substituted THF and tetrahydropyran and 1,4-dioxane, which is less reactive. (C) 2004 Elsevier Ltd. All rights reserved.
• Regio- and enantioselectivity of Pseudomonas cepacia lipase in the transesterification of 2-substituted-1,4-butanediols
  作者：Patrizia Ferraboschi、Paride Grisenti、Ada Manzocchi、Enzo Santaniello

  DOI：10.1016/0957-4166(94)80031-6

  日期：1994.4

  The transesterification of 2-substituted-1,4-butanediols 1a, 2a and 3a with vinyl acetate catalyzed by the Pseudomonas cepacia lipase in organic solvents affords preferentially the 1-acetate, the highest regioselectivity having been found for the epoxydiol 3a, which is enantioselectively resolved [86% ee for the unreacted (S)-(-)-3a].
• Harries; Neresheimer, Justus Liebigs Annalen der Chemie, 1911, vol. 383, p. 169
  作者：Harries、Neresheimer

  DOI：——

  日期：——
• Incorporation of 2-C-Methyl-d-erythritol, a Putative Isoprenoid Precursor in the Mevalonate-Independent Pathway, into Ubiquinone and Menaquinone of Escherichia coli
  作者：Tore Duvold、Patrizia Calí、Jean-Michel Bravo、Michel Rohmer

  DOI：10.1016/s0040-4039(97)01392-0

  日期：1997.9

  Incorporation of deuterium labelled 2-C-methyl-D-erythritol into isoprenoid side-chains of ubiquinone and menaquinone from Escherichia coli strongly supports the proposed intermediate role of this branched sugar derivative in the mevalonate independent pathway for isoprenoid biosynthesis via glyceraldehyde 3-phosphate and pyruvate. (C) 1997 Published by Elsevier Science Ltd.