1,4-二乙酰氧基蒽 | 24301-50-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 1,4-二乙酰氧基蒽
• 英文名称: anthracene-1,4-diacetate
• 英文别名: 1,4-diacetoxyanthracene；1,4-diacetoxy-anthracene；1,4-Diacetoxy-anthracen；Anthracene-1,4-diyl diacetate；(4-acetyloxyanthracen-1-yl) acetate
• CAS: 24301-50-6
• 化学式: C₁₈H₁₄O₄
• 分子量: 294.307
• InChiKey: SARCGSJLIZFGFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2915390090

反应信息

• 作为反应物：
  描述：

  1,4-二乙酰氧基蒽 在 铬酸 、 溶剂黄146 作用下， 生成 (4-乙酰氧基-9,10-二氧代蒽-1-基)乙酸酯
  参考文献：
  名称：

  Haslinger, Chemische Berichte, 1906, vol. 39, p. 3537

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-蒽醌 生成 1,4-二乙酰氧基蒽
  参考文献：
  名称：

  Haslinger, Chemische Berichte, 1906, vol. 39, p. 3537

  摘要：

  DOI：

文献信息

• Facile Synthesis of Triptycene‐Azolium Salts and NHC‐Metal Complexes
  作者：Alexander Kaps、Herbert Plenio

  DOI：10.1002/ejic.202300178

  日期：2023.6.23

  The cycloaddition of substituted anthracenes and quinone-imines is the key step in the facile synthesis of new triptycene-NHC-metal complexes.

  取代的蒽和醌亚胺的环加成是轻松合成新型三蝶烯-NHC-金属配合物的关键步骤。
• Harrison, Charles R.; Hodge, Philip; Khan, Naeem, Journal of the Chemical Society. Perkin transactions I, 1980, p. 1592 - 1594
  作者：Harrison, Charles R.、Hodge, Philip、Khan, Naeem

  DOI：——

  日期：——
• Dienel, Chemische Berichte, 1906, vol. 39, p. 932
  作者：Dienel

  DOI：——

  日期：——
• Antitumor agents. II. Bis(guanylhydrazones) of anthracene-9,10-dicarboxaldehydes
  作者：K. C. Murdock、R. G. Child、Yang I Lin、J. D. Warren、P. F. Fabio、Ving J. Lee、P. T. Izzo、S. A. Lang、Robert B. Angier

  DOI：10.1021/jm00347a006

  日期：1982.5

  9,10-Anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] (bisantrene, VI-1) showed anticancer activity in mice vs. both leukemias and solid tumors. Increases in life span vs. the following neoplasms were: P-388 leukemia, 137%; B-16 melanoma, 122%; Lieberman plasma cell tumor, greater than 85%; colon tumor 26, 150%; Ridgway osteogenic sarcoma, 85%. There were significant numbers of long-term survivors. Both DNA and RNA synthesis were strongly inhibited. The drug was resistant to biodegradation and was bound strongly to tissues; in monkeys the half-life for disappearance from serum was 6 days. Related hydrazones were synthesized, and structure-activity relationships are discussed. Two routes to ring-substituted anthracene-9,10-dicarboxaldehyde intermediates were developed.
• Phosphorylation and cyclophosphorylation of 1,4-diacetoxyanthracene and dianthrone
  作者：E. N. Rasadkina、A. V. Petrov、E. E. Nifant’ev

  DOI：10.1134/s1070363207020090

  日期：2007.2

  Phosphorylation and cyclophosphorylation of 1,4-dihydroxyanthracene and dianthrone by hexaalkylphosphorous triamides in pyridine was effected for the first time. The phosphorylation rate is found depending on the type of the alkyl fragment in the amido group of the phosphorylating agent. Cyclic phosphoramidites derived from anthracene were prepared both by molecular assembling and direct cyclophosphorylation. Thio and oxo derivatives of these cyclic compounds were obtained. Dianthrone derivatives undergo intramolecular cycloaddition at only one anthracene fragment to form an interesting bulky structure containing the phospholane ring.