1,4-环己烷二碳酰肼 | 27327-67-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,4-环己烷二碳酰肼
• 英文名称: cyclohexane-1,4-dicarbohydrazide
• 英文别名: 1,4-Cyclohexanedicarbohydrazide
• CAS: 27327-67-9
• 化学式: C₈H₁₆N₄O₂
• mdl: MFCD00043475
• 分子量: 200.241
• InChiKey: LPLAXQKUDSKKAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  1,4-环己烷二碳酰肼 、 靛红 生成 1-N',4-N'-bis(2-oxoindol-3-yl)cyclohexane-1,4-dicarbohydrazide
  参考文献：
  名称：

  POPP, F. D., J. HETEROCYCL. CHEM., 1984, 21, N 6, 1641-1645

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-环己烷二甲酸 在 硫酸 、 一水合肼 作用下， 以 甲醇 为溶剂， 反应 0.4h， 生成 1,4-环己烷二碳酰肼
  参考文献：
  名称：

  连续流动中由羧酸合成酰肼

  摘要：

  描述了一种通过连续流动工艺从羧酸合成酰肼的简明方法，收率范围为 65% 至 91%。事实证明，该条件适用于 13 至 25 分钟的短停留时间，适用于各种一元酸和二元酸，包括脂肪族、芳香族和杂芳香族官能团。为了证明可扩展性，在连续 9 小时的时间内进行了壬二酸二酰肼的大规模（200 克）合成，总产率为 86%，相当于 22 克/小时的产量。

  DOI：

  10.1021/acs.oprd.3c00216

文献信息

• Ultralow‐Molecular‐Weight Stimuli‐Responsive and Multifunctional Supramolecular Gels Based on Monomers and Trimers of Hydrazides
  作者：Dehua Wu、Jintong Song、Lang Qu、Weilan Zhou、Lei Wang、Xiangge Zhou、Haifeng Xiang

  DOI：10.1002/asia.202001041

  日期：2020.10.16

  cyclohexane‐derived hydrazides, their monomers can self‐assemble to form gels through intermolecular hydrogen bonds and dipole‐dipole interactions. Significantly, conjugated phthalhydrazide can self‐aggregate into planar and circular trimers through intermolecular hydrogen bonds and then self‐assemble to form gels through intermolecular π–π stacking interactions. It is interesting that these simple gelators

  越简单越好。设计并合成了一系列简单，中性和超低分子量（MW：140–200）的酰肼类超分子凝胶剂，并通过两个简单的步骤进行了合成。对于非共轭的衍生自环己烷的酰肼，它们的单体可以通过分子间氢键和偶极-偶极相互作用自组装形成凝胶。重要的是，共轭邻苯二甲酰肼可以通过分子间氢键自聚集成平面和圆形三聚体，然后通过分子间π-π堆积相互作用自组装形成凝胶。有趣的是，这些简单的胶凝剂表现出不同寻常的特性，例如自我修复，多响应荧光以及手性（R）/（S）-1,1'-联萘-2,2'-二胺和S 2−分别通过不同的凝胶重整时间和蓝绿色变色时间。这些结果强调了超分子凝胶的重要性，并扩展了超分子胶凝剂的范围。
• Aqueous emulsion, process for producing the same and aqueous paint and aqueous printing ink comprising the same
  申请人：NIPPON POLYURETHANE INDUSTRY CO. LTD.

  公开号：EP1057843A1

  公开（公告）日：2000-12-06

  An aqueous emulsion which comprises as a resin component a self-emulsifiable copolymer in which at least one ethylenically unsaturated monomer and at least one urethane prepolymer having at least one mercapto group and at least one hydrophilic, polar group are bonded by radical polymerization or in which at least one ethylenically unsaturated monomer, at least one organic polyisocyanate, at least one compound having at least one mercapto group and at least one active hydrogen-containing group and at least one compound having at least one hydrophilic, polar group and at least one active hydrogen-containing group are bonded by urethanization reaction and radical polymerization.

  一种水性乳液，作为树脂组分包括一种自乳化共聚物，其中至少有一种乙烯基不饱和单体和至少一种具有至少一个巯基和至少一个亲水极性基团的聚氨酯预聚物通过自由基聚合键合，或至少有一种乙烯基不饱和单体、至少一种有机多异氰酸酯、至少一种具有至少一个巯基和至少一个活性含氢基团的化合物，以及至少一种具有至少一个亲水极性基团和至少一个活性含氢基团的化合物，通过氨基甲酸酯化反应和自由基聚合键合。
• STAINPROOFING AGENTS, COATING COMPOSITIONS CONTAINING THE SAME AND COATED ARTICLES
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP1422280A1

  公开（公告）日：2004-05-26

  The invention provides stain-proofing agents capable of forming coating films excellent in rain streak stain resistance and durability thereof, coating compositions comprising the stain-proofing agents, and articles coated therewith. A stain-proofing agent comprising a polymer which contains at least one repeating unit having at least two hydroxyl groups, wherein the content (by mass) of the repeating unit is more than 10%. A stain-proofing agent comprising a polymer which contains at least two repeating units having hydroxymethyl groups, wherein the content (by mass) of the repeating unit is more than 30%. A coating composition comprising such a stain-proofing agent and a coating resin such as a fluororesin.

  本发明提供了能够形成具有优异防雨条纹污渍性能和耐久性的涂膜的防污剂、包含该防污剂的涂料组合物以及涂有该防污剂的物品。 一种由聚合物组成的防污剂，该聚合物含有至少一个具有至少两个羟基的重复单元，其中重复单元的含量（按质量计）超过 10%。一种防污剂，包含至少两个具有羟甲基的重复单元的聚合物，其中重复单元的含量 （按质量计）超过 30%。一种涂料组合物，由上述防污剂和涂料树脂（如氟树脂）组成。
• SELF−REACTIVE/CURABLE WATER−BASED SOLID ADHESIVE AND METHOD OF BONDING WITH THE SELF−REACTIVE/CURABLE WATER−BASED SOLID ADHESIVE
  申请人：KONISHI CO., LTD.

  公开号：EP1431366A1

  公开（公告）日：2004-06-23

  Self-curable water-based solid adhesives ofthisinvention include the following components (A), (B), (C), and (D): (A) an anionic-group-containing polymer terminally having an alkoxysilyl group, the polymer being a reaction product of a compound (A1) containing no anionic group and having plural isocyanate-reactive groups, a compound (A2) having an anionic group and plural isocyanate-reactive groups, a polyisocyanate compound (A3), and an alkoxysilane compound (A4) containing an isocyanate-reactive group; (B) a basic compound; (C) water; and (D) a gelling agent. The self-curable water-based solid adhesives of the present invention can be applied with good workability, have good fitting after attachment, have good adhesion to plastics, metals and glass and exhibit excellent heat resistance and water resistance after curing. They are highly safe to humans and the environment. They also have excellent shape retention and slidability and can be easily applied. In addition, they can bond adherends by contact bonding despite that they are water-based solid adhesives. Accordingly, the self-curable water-based solid adhesives of this invention are very useful as stick adhesives.

  本发明的自固化水基固体粘合剂包括以下成分 (A)、(B)、(C) 和 (D)： (A) 末端具有烷氧基硅烷基团的含阴离子基团聚合物，该聚合物是不含阴离子基团且具有多个异氰酸酯反应基团的化合物 (A1)、具有阴离子基团和多个异氰酸酯反应基团的化合物 (A2)、多异氰酸酯化合物 (A3) 和含有异氰酸酯反应基团的烷氧基硅烷化合物 (A4) 的反应产物； (B) 碱性化合物 (C) 水；以及 (D) 胶凝剂。 本发明的自固化水基固体粘合剂在使用时具有良好的可操作性，粘合后具有良好的贴合性，与塑料、金属和玻璃具有良好的粘合性，固化后具有优异的耐热性和耐水性。它们对人体和环境高度安全。它们还具有出色的形状保持性和滑动性，并且易于涂抹。此外，尽管它们是水基固体粘合剂，但可以通过接触粘合的方式粘合被粘物。因此，本发明的自固化水基固体粘合剂作为粘性粘合剂非常有用。
• AQUEOUS SILYLATED URETHANE COMPOSITION, AQUEOUS ADHESIVES FOR WRAPPING, AND AQUEOUS CONTACT ADHESIVES
  申请人：KONISHI CO., LTD.

  公开号：EP1607423A1

  公开（公告）日：2005-12-21

  A water-based silylated urethane composition is used as a water-based adhesive that has high safety, develops satisfactory tackiness in a short time and has excellent initial bond strength. The water-based silylated urethane composition contains following Components (A), (B) and (C): (A) a urethane prepolymer containing an anionic group and a tertiary amino group and having a terminal alkoxysilyl group, the urethane prepolymer (A) being a reaction product of an anionic-group-free polyol compound (A1), an anionic-group-containing polyol compound (A2), a compound (A3) containing a tertiary amino group and an isocyanate-reactive group, a polyisocyanate compound (A4), an alkoxysilane compound (A5) containing an isocyanate-reactive group, and an amine-based chain extender (A6); (B) a basic compound; and (C) water

  一种水基硅烷化聚氨酯组合物可用作水基粘合剂，它具有很高的安全性，能在短时间内产生令人满意的粘性，并具有出色的初始粘合强度。水基硅烷化聚氨酯组合物包含以下成分（A）、（B）和（C）： (A) 含有阴离子基团和叔氨基且具有末端烷氧基硅烷基团的聚氨酯预聚物，聚氨酯预聚物 (A) 是不含阴离子基团的多元醇化合物 (A1)、含阴离子基团的多元醇化合物 (A2) 的反应产物、一种含有叔氨基和异氰酸酯反应基团的化合物 (A3)、一种多异氰酸酯化合物 (A4)、一种含有异氰酸酯反应基团的烷氧基硅烷化合物 (A5) 和一种胺基扩链剂 (A6)； (B) 碱性化合物；以及 (C) 水