新丙戊酯 | 77372-61-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 新丙戊酯
• 中文别名: 丙戊匹酯
• 英文名称: Valproate pivoxil
• 英文别名: 2,2-dimethylpropanoyloxymethyl 2-propylpentanoate
• CAS: 77372-61-3
• 化学式: C₁₄H₂₆O₄
• mdl: MFCD00865285
• 分子量: 258.35
• InChiKey: DJEFRLDEQKSNLM-UHFFFAOYSA-N

物化性质

• 沸点：
  315.3±15.0 °C(Predicted)
• 密度：
  0.967±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙戊酸 、 特戊酸氯甲酯 生成 新丙戊酯
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• [EN] INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES<br/>[FR] DERIVES D'INDOLONE-ACETAMIDE, LEURS PROCEDES DE PREPARATION ET LEURS UTILISATIONS
  申请人：UCB SA

  公开号：WO2004087658A1

  公开（公告）日：2004-10-14

  The present invention relates to indolone-acetamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as for the treatment of epilepsy, epileptogenesis, seizure disorders and convulsion.

  本发明涉及吲哚酮-乙酰胺衍生物，其制备方法，含有它们的药物组合物以及它们用于治疗癫痫、癫痫发作、抽搐障碍的用途。
• [EN] IMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES<br/>[FR] DERIVES D'IMIDAZOLE, LEURS PROCEDES DE PREPARATION ET LEURS UTILISATIONS
  申请人：UCB SA

  公开号：WO2005054188A1

  公开（公告）日：2005-06-16

  The present invention relates to imidazole derivatives of the formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

  本发明涉及式(I)的咪唑衍生物，制备它们的方法，含有它们的药物组合物以及它们作为药物的用途。
• NOVEL URSOLIC ACID DERIVATIVE AND METHOD FOR PREPARING SAME
  申请人：Nexoligo Co., Ltd.

  公开号：US20150218206A1

  公开（公告）日：2015-08-06

  The present invention relates to a novel ursolic acid derivative as an ursolic acid prodrug form, and to a method for preparing same, wherein the novel ursolic acid derivative as an ursolic acid prodrug can have excellent pharmacokinetic characteristics such as stability and oral absorptivity and exhibit excellent pharmaceutical activities by being converted into an ursolic acid in vivo, and. The ursolic acid derivative can be in an ester form in which C28 carboxylic acid in the ursolic acid is combined with a prodrug of a certain pharmaceutical compound.

  本发明涉及一种新颖的熊果酸衍生物作为熊果酸前药形式，以及制备该衍生物的方法，其中作为熊果酸前药的新颖熊果酸衍生物可以具有优秀的药代动力学特性，如稳定性和口服吸收性，并通过在体内转化为熊果酸而展现出优秀的药用活性。该熊果酸衍生物可以以酯形式存在，其中熊果酸中的C28羧酸与某种药物化合物的前药结合。
• 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their use
  申请人：UCB S.A.

  公开号：EP1577296A1

  公开（公告）日：2005-09-21

  The invention concerns (2S)-2-[4-(2,2-difluoroviny)-2-oxopyrrolidin-1-yl]butanoic acid and stereoisomers thereof.

  本发明涉及(2S)-2-[4-(2,2-二氟乙烯基)-2-氧代吡咯烷-1-基]丁酸及其立体异构体。
• 2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
  申请人：Differding Edmond

  公开号：US20050171188A1

  公开（公告）日：2005-08-04

  The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.

  本发明涉及式I的2-氧代-1-吡咯烷衍生物，其中取代基如规范中所定义，以及它们作为药物的用途。本发明的化合物特别适用于治疗癫痫等神经系统疾病。