1-(1H-吲哚-1-基)甲胺 | 214204-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 1-(1H-吲哚-1-基)甲胺
• 英文名称: 1H-Indole-1-methanamine
• 英文别名: indol-1-ylmethanamine
• CAS: 214204-10-1
• 化学式: C₉H₁₀N₂
• 分子量: 146.19
• InChiKey: PARWCHOPLKCWOC-UHFFFAOYSA-N

物化性质

• 沸点：
  283.9±23.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  31
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• BIS-PHOSPHATE COMPOUND AND ASYMMETRIC REACTION USING THE SAME
  申请人：Terada Masahiro

  公开号：US20120330038A1

  公开（公告）日：2012-12-27

  A novel bis-phosphate compound is provided which can be applied to a wide range of reactive substrates and reactions as an asymmetric reaction catalyst and can realize an asymmetric reaction affording a high yield and a high enantiomeric excess. The bis-phosphate compound has a tetraaryl skeleton represented by General Formula (1). In an asymmetric reaction, an amidodiene and an unsaturated aldehyde compound are reacted with each other in the presence of the optically active bis-phosphate compound to give an optically active amidoaldehyde. The invention allows a reaction such as an asymmetric Diels-Alder reaction to proceed efficiently, which has been difficult with conventional mono-phosphate compounds. Thus, the invention enables an industrially feasible method for the production of optically active amidoaldehydes, optically active β-amino acid derivatives, optically active diamine compounds, optically active pyrrolidine derivatives and optically active dihydropyran derivatives which are useful as products such as medicines, agricultural chemicals and chemical products as well as synthesis intermediates for such products.

  提供了一种新型的双磷酸盐化合物，可应用于广泛的反应底物和反应作为不对称反应催化剂，并且可以实现产率高和对映体过量高的不对称反应。该双磷酸盐化合物具有由通用式（1）表示的四芳基骨架。在不对称反应中，存在光学活性的双磷酸盐化合物的情况下，通过使酰胺二烯和不饱和醛化合物相互反应，得到光学活性的酰胺醛。该发明使得像不对称Diels-Alder反应这样的反应能够高效进行，而传统的单磷酸盐化合物很难实现。因此，该发明实现了一种工业上可行的方法，用于生产用作药品、农药和化工产品以及用于这些产品的合成中间体的光学活性酰胺醛、光学活性β-氨基酸衍生物、光学活性二胺化合物、光学活性吡咯烷衍生物和光学活性二氢吡喃衍生物。
• Water soluble fluorescent compounds
  申请人：Reddington Mark

  公开号：US20070021621A1

  公开（公告）日：2007-01-25

  The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.

  这项发明提供了一类新型荧光化合物。还提供了荧光化合物的共轭物，使用荧光化合物及其共轭物的方法，以及包括荧光化合物及其共轭物的试剂盒。
• [EN] 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Ie<br/>[FR] AMIDES DE L'ACIDE 5- ET 6-AMINOALKYL INDOLE-2-CARBOXYLIQUE SUBSTITUÉ EN POSITION 3 ET ANALOGUES APPARENTÉS EN TANT QU'INHIBITEURS DE LA CASÉINE KINASE I EPSILON
  申请人：AVENTIS PHARMA INC

  公开号：WO2006023467A1

  公开（公告）日：2006-03-02

  The present invention discloses and claims compounds of formula (I) and formula (II) as inhibitors of human casein kinase Iϵ, and methods of using said compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) are also disclosed and claimed.

  本发明揭示并声明公式(I)和公式(II)的化合物作为人类酪蛋白激酶Iϵ的抑制剂，并使用公式(I)和公式(II)的这些化合物治疗包括情绪障碍和睡眠障碍在内的中枢神经系统疾病和疾病的方法。还揭示和声明了包含公式(I)或公式(II)化合物的药物组合物。
• 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I
  申请人：METZ, JR. William Arthur

  公开号：US20090082340A1

  公开（公告）日：2009-03-26

  The present invention discloses and claims methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the administration of a compounds of formula (I) and formula (II) as inhibitors of human casein kinase Iε, and methods of using said compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) useful in the claimed methods of treatment are also disclosed.

  本发明揭示和声明了治疗因抑制酪蛋白激酶Iε活性而改善的疾病或疾病患者的方法，包括给予公式（I）和公式（II）化合物作为人类酪蛋白激酶Iε的抑制剂，并使用公式（I）和公式（II）化合物治疗中枢神经系统疾病和疾病，包括情绪障碍和睡眠障碍的方法。本文中定义了R基取代基，还揭示了包含公式（I）或公式（II）化合物的制药组合物，可用于所声明的治疗方法。
• WATER SOLUBLE FLUORESCENT COMPOUNDS
  申请人：REDDINGTON MARK

  公开号：US20110294118A1

  公开（公告）日：2011-12-01

  The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.

  本发明提供了一种新型荧光化合物。还提供了荧光化合物的结合物，使用荧光化合物及其结合物的方法以及包括荧光化合物及其结合物的试剂盒。