1-(2,4,6-三甲氧基苯基)-2-丙炔-1-醇 | 61040-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(2,4,6-三甲氧基苯基)-2-丙炔-1-醇
• 英文名称: 1-(2,4,6-trimethoxyphenyl)prop-2-yn-1-ol
• 英文别名: 1-(2,4,6-Trimethoxyphenyl)-prop-2-in-1-ol
• CAS: 61040-72-0
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: SWTIFAXMKKYMLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2909499000

反应信息

• 作为反应物：
  描述：

  1-(2,4,6-三甲氧基苯基)-2-丙炔-1-醇 在 copper(l) iodide 、 Mo(CO)3(CN-t-Bu)3 、 二异丙胺 、 对苯二酚 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 生成 3-tributylstannyl-1-(2,4,6-trimethoxy-phenyl)-but-3-en-1-ol
  参考文献：
  名称：

  Syntheses and Synthetic Applications of Stannylated Allylic Alcohols

  摘要：

  Allenyl carbinols undergo regioselective hydrostannation in the presence of MoBl(3), a catalyst originally developed for the hydrostannation of alkynes, giving rise to allyl stannanes, These allyl stannanes can easily be converted into useful synthetic building blocks such as allyl iodides or vinyl epoxides.

  DOI：

  10.1021/jo052611l
• 作为产物：
  描述：

  2,4,6-三甲氧基苯甲醛 、 乙炔基溴化镁 以 四氢呋喃 为溶剂， 生成 1-(2,4,6-三甲氧基苯基)-2-丙炔-1-醇
  参考文献：
  名称：

  金（I）催化的炔丙基缩醛和炔烃的串联环化反应

  摘要：

  为了扩大对炔丙基缩醛化学的认识，已经研究了它们的金（I）与炔烃催化的环加成反应。我们据此报告了一种新颖的串联反应，该串联反应允许构建新型的多取代和高度官能化的双环戊烯化合物2,6a-二甲氧基-3a-甲基-1,4,5-三苯基-1,3a，4,6a-四氢戊烯，具有四个立体异构中心。 从非对映异构产物的混合物中成功分离出纯度最高为51％的纯非对映异构体（总产率高达60％），并通过NMR光谱法进行了单独表征。对于这种金（I）催化的反应，提出了基于随后的[2 + 2]和[2 + 3]环加成反应形成这些新型串联产物的合理机制。

  DOI：

  10.1016/j.tet.2015.12.080

文献信息

• [EN] 2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE<br/>[FR] 2,4,6-TRIALCOXYSTYRYLARYLSULFONES, SULFONAMIDES ET CARBOXAMIDES, ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：TEMPLE UNIV - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：WO2017023912A1

  公开（公告）日：2017-02-09

  Compounds according to Formula (I) are provided and salts thereof, wherein R1, R2, R3, R4, R5, R6, R13, A, X and Y are as defined herein. Methods for preparing compounds of Formula (I) are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I).

  根据公式（I）提供化合物及其盐，其中R1、R2、R3、R4、R5、R6、R13、A、X和Y的定义如本文所述。还提供了制备公式（I）化合物的方法，以及利用公式（I）化合物治疗细胞增殖性疾病，如癌症的方法。
• Molybdenum-catalyzed hydrostannations of allenylcarbinols
  作者：Uli Kazmaier、Manuela Klein

  DOI：10.1039/b413025a

  日期：——

  Allenylcarbinols undergo regioselective hydrostannation in the presence of MoBl3, a catalyst which was developed for the hydrostannation of propargyl alcohols and derivatives; allylstannanes are formed preferentially, which can easily be converted into allyl iodides.

  烯丙基甲醇在MoBl3存在下进行区域选择性氢锡化，MoBl3是为炔丙醇及其衍生物的氢锡化而开发的催化剂。优先形成烯丙基锡烷，可以容易地将其转化为烯丙基碘。
• 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
  申请人：Temple University—Of The Commonwealth System Of Higher Education

  公开号：US10383831B2

  公开（公告）日：2019-08-20

  Compounds according to Formula I are provided: and salts thereof, wherein R1, R2, R3, R4, R5, R6, R13, A, X and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula I.

  提供了符合式 I 的化合物： 及其盐类，其中 R1、R2、R3、R4、R5、R6、R13、A、X 和 Y 如本文所定义。还提供了制备式 I 化合物的方法，以及使用式 I 化合物治疗细胞增殖性疾病（如癌症）的方法。
• (<i>Z</i>)-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure–Activity Relationship (SAR), Tubulin Polymerization, and Cell Growth Inhibition Studies
  作者：M. V. Ramana Reddy、Balaiah Akula、Stephen C. Cosenza、Clement M. Lee、Muralidhar R. Mallireddigari、Venkat R. Pallela、D. R. C. Venkata Subbaiah、Andrew Udofa、E. Premkumar Reddy

  DOI：10.1021/jm300176j

  日期：2012.6.14

  Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-aryl-3-arylamino-2-propen-1-one (10) were synthesized and evaluated for antiproliferative activity in cell-based assay. The most active compound (Z)-1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one (10ae) was tested in 20 tumor cell lines including multidrug resistant phenotype and was found to induce apoptosis in all these cell lines with similar GI(50) values. Flow cytometry studies showed that 10ae arrested the cells in G2/M phase of cell cycle. In addition to G2/M block, these compounds caused microtubule stabilization like paclitaxel and induced apoptosis via activation of the caspase family. The observations made in this investigation demonstrate that (Z)-1-Aryl-3-arylamino-2-propen-1-one (10) represents a new class of microtubule-stabilizing agents.
• Midgley,J.M. et al., Journal of the Chemical Society. Perkin transactions I, 1976, p. 1384 - 1385
  作者：Midgley,J.M. et al.

  DOI：——

  日期：——