1-(2-氨基苯基)吡咯烷-3-醇 | 955398-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(2-氨基苯基)吡咯烷-3-醇
• 英文名称: 1-(2-Aminophenyl)pyrrolidin-3-ol
• CAS: 955398-56-8
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: JOMIFNBQNVZIIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  1-(2-氨基苯基)吡咯烷-3-醇 、 5-硝基-2-糠酰氯 在 PS-morpholine 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 N-(2-(3-hydroxypyrrolidin-1-yl)phenyl)-5-nitrofuran-2-carboxamide
  参考文献：
  名称：

  Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

  摘要：

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.057
• 作为产物：
  描述：

  C₁₀H₁₂N₂O₃ 在 palladium on activated charcoal 氢气 、 溶剂黄146 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 生成 1-(2-氨基苯基)吡咯烷-3-醇
  参考文献：
  名称：

  Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

  摘要：

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.057

文献信息

• AZOLECARBOXAMIDE DERIVATIVE
  申请人：Sugasawa Keizo

  公开号：US20090286766A1

  公开（公告）日：2009-11-19

  Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.

  提供了一种用于治疗或预防与过度活跃膀胱、下泌尿道疾病（如间质性膀胱炎和慢性前列腺炎伴随下泌尿道疼痛）以及伴随疼痛的各种疾病相关的尿频、尿急和尿失禁的药剂。一种新型的唑烷羧酰胺衍生物，其中唑环（如硫唑环或噁唑环）通过羧酰胺键连接到苯环、吡啶环或嘧啶环上，被证实具有强效的trkA受体抑制活性，并被发现是一种用于治疗或预防下泌尿道疾病和伴随疼痛的各种疾病的药剂，其疗效和安全性优异，因此本发明得以完成。
• Methods for Using Carboxamide, Sulfonamide and Amine Compounds
  申请人：RIGEL PHARMACEUTICALS, INC.

  公开号：US20140323460A1

  公开（公告）日：2014-10-30

  Disclosed are uses of carboxamide, sulfonamide and amine compounds for the treatment and amelioration of disorders and conditions related to oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. Also described are methods for increasing exercise endurance, exercise efficiency and aerobic workload using the compounds described herein.
• US8163746B2
  申请人：——

  公开号：US8163746B2

  公开（公告）日：2012-04-24
• [EN] COSMETIC COMPOSITION FOR KERATIN FIBERS<br/>[FR] COMPOSITION COSMÉTIQUE POUR DES FIBRES KÉRATINIQUES
  申请人：OREAL

  公开号：WO2013069166A1

  公开（公告）日：2013-05-16

  The present invention relates to a cosmetic composition for keratin fibers, in a mousse form, comprising: (a) at least one fatty material; (b) at least one glucoside type surfactant; (c) at least one non-volatile alkaline agent; and (d) at least one oxidizing agent, and (e) at least one foam stabilizer wherein the amount of the (a) fatty material (s) is 20% by weight or more, preferably 30% by weight or more, and more preferably 40% by weight or more, relative to the total weight of the composition. The present invention is useful, because the cosmetic composition according to the present invention can have good foamability as well as good bleaching or coloring ability, without offensive odor from ammonia.
• Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents
  作者：Raymond J. Patch、Benjamin M. Brandt、Davoud Asgari、Nand Baindur、Naresh K. Chadha、Taxiarchis Georgiadis、Wing S. Cheung、Ioanna P. Petrounia、Robert R. Donatelli、Margery A. Chaikin、Mark R. Player

  DOI：10.1016/j.bmcl.2007.09.057

  日期：2007.11

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.