The invention relates to novel biodegradable materials which are based on modified polyamino acids and which can be used for the vectorisation of active principle(s) (AP). The invention also relates to novel pharmaceutical, cosmetic, dietary or phytosanitary compositions based on said polyamino acids. The aim of the invention is to provide a novel polymer raw material which can be used for the vectorisation of active principles and which can optimally fulfil all required specifications in said area, namely: biocompatibility, biodegradability and the ability to become easily associated with many active principles or to solubilise said principles and to release same in vivo. Said aim is achieved with novel copolyhydroxyalkylglutamines comprising glutamine units and optionally glutamate units and bearing hydrophobic groups containing between 8 and 30 carbon atoms. Said copolyhydroxyalkylglutamines are amphiphilic and can be easily and economically transformed into particles for the vectorisation of active principles, whereby said particles can form stable aqueous colloidal suspensions.
该发明涉及基于改性聚
氨基酸的新型可
生物降解材料,可用于活性成分的载体化。该发明还涉及基于这些聚
氨基酸的新型药用、化妆品、膳食或植物保护组合物。该发明的目的是提供一种新型聚合物原料,可用于活性成分的载体化,并能够最佳地满足该领域中所有所需规格,即
生物相容性、
生物降解性以及能够轻松与许多活性成分结合或溶解这些成分并在体内释放的能力。通过包含谷
氨酰胺单元和可选的谷
氨酸单元以及带有含有8至30个碳原子的疏
水基团的新型共聚羟基烷基谷
氨酰胺,实现了该目的。这些共聚羟基烷基谷
氨酰胺是两性的,可以轻松且经济地转化为用于活性成分载体化的颗粒,这些颗粒可以形成稳定的
水胶体悬浮液。