月桂酸-(2-氨基-乙基酯) | 78616-98-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 月桂酸-(2-氨基-乙基酯)
• 英文名称: lauric acid-(2-amino-ethyl ester)
• 英文别名: Laurinsaeure-(2-amino-aethylester)；1-Amino-2-lauroyloxy-aethan；2-Aminoethyl dodecanoate
• CAS: 78616-98-5
• 化学式: C₁₄H₂₉NO₂
• 分子量: 243.39
• InChiKey: WEJWRPYVWRFROR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  月桂酸-(2-氨基-乙基酯) 在 三乙胺 、 N,N-二异丙基乙胺 、 magnesium chloride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 36.0h， 生成 2-(((((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)ethyl dodecanoate
  参考文献：
  名称：

  [EN] ANTIVIRAL COMPOUNDS
  [FR] COMPOSÉS ANTIVIRAUX

  摘要：

  本公开提供了用于治疗各种疾病的化合物，如呼吸道合胞病毒（RSV）、人 rhinovirus（HRV）、人类副流感病毒（hMPV）、埃博拉病毒、寨卡病毒、西尼罗河病毒、登革热病毒和丙型肝炎病毒（HCV）。

  公开号：

  WO2021167882A1
• 作为产物：
  描述：

  2-((tert-butoxycarbonyl)amino)ethyl dodecanoate 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 以26%的产率得到月桂酸-(2-氨基-乙基酯)
  参考文献：
  名称：

  Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

  摘要：

  N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 mu M), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.03.065

文献信息

• COPOLYHYDROXYALKYLGLUTAMINES FUNCTIONALISED WITH HYDROPHOBIC GROUPS, AND USES THEREOF, ESPECIALLY IN THERAPEUTICS
  申请人：Soula Rémi

  公开号：US20110044930A1

  公开（公告）日：2011-02-24

  The invention relates to novel biodegradable materials which are based on modified polyamino acids and which can be used for the vectorisation of active principle(s) (AP). The invention also relates to novel pharmaceutical, cosmetic, dietary or phytosanitary compositions based on said polyamino acids. The aim of the invention is to provide a novel polymer raw material which can be used for the vectorisation of active principles and which can optimally fulfil all required specifications in said area, namely: biocompatibility, biodegradability and the ability to become easily associated with many active principles or to solubilise said principles and to release same in vivo. Said aim is achieved with novel copolyhydroxyalkylglutamines comprising glutamine units and optionally glutamate units and bearing hydrophobic groups containing between 8 and 30 carbon atoms. Said copolyhydroxyalkylglutamines are amphiphilic and can be easily and economically transformed into particles for the vectorisation of active principles, whereby said particles can form stable aqueous colloidal suspensions.

  该发明涉及基于改性聚氨基酸的新型可生物降解材料，可用于活性成分的载体化。该发明还涉及基于这些聚氨基酸的新型药用、化妆品、膳食或植物保护组合物。该发明的目的是提供一种新型聚合物原料，可用于活性成分的载体化，并能够最佳地满足该领域中所有所需规格，即生物相容性、生物降解性以及能够轻松与许多活性成分结合或溶解这些成分并在体内释放的能力。通过包含谷氨酰胺单元和可选的谷氨酸单元以及带有含有8至30个碳原子的疏水基团的新型共聚羟基烷基谷氨酰胺，实现了该目的。这些共聚羟基烷基谷氨酰胺是两性的，可以轻松且经济地转化为用于活性成分载体化的颗粒，这些颗粒可以形成稳定的水胶体悬浮液。
• Compositions of matter having bioactive properties
  申请人：Schmitz, Robert A.

  公开号：EP1288238A1

  公开（公告）日：2003-03-05

  Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.

  描述了由基础水合聚合物和电容添加化合物组成的协调复合物的颗粒，以及它们的生产方法。这些复合物表现出很高的生物活性，使它们适用于广泛的应用领域，通过将它们纳入传统载体中，从而受益于抗菌和类似性能。
• [EN] IMPROVED PROCESS FOR ALAKNOLAMIDE SYNTHESIS<br/>[FR] PROCÉDÉ AMÉLIORÉ DE SYNTHÈSE D'ALCANOLAMIDES
  申请人：CHEVRON ORONITE CO

  公开号：WO2016032911A1

  公开（公告）日：2016-03-03

  The present invention is directed to a process of making alkanolamides wherein the "aging" time is reduced and the diethanol amide to ester ratio in the finished product is increased. Further provided is an additive composition comprising an alkanolamide which contains a reduced amount of DEA and BHEP.

  本发明涉及一种制备烷醇酰胺的方法，其中“老化”时间缩短，成品中二乙醇酰胺与酯的比例增加。此外，提供一种添加剂组合物，包括含有减少量 DEA 和 BHEP 的烷醇酰胺。
• Anionic polysaccharides functionalized by a hydrophobic acid derivative
  申请人：CHARVET Richard

  公开号：US20110172166A1

  公开（公告）日：2011-07-14

  A novel anionic polysaccharides functionalized by at least one hydrophobic acid derivative. These novel anionic polysaccharides including hydrophobic groups have good biocompatibility and their hydrophobicity can be easily adjusted without detrimentally affecting the biocompatibility or the stability. A method of synthesis which makes it possible to produce them and to pharmaceutical compositions including them.

  一种由至少一种疏水酸衍生物功能化的新型阴离子多糖。这些包含疏水基团的新型阴离子多糖具有良好的生物相容性，它们的疏水性可以轻松调整，而不会对生物相容性或稳定性造成不利影响。提供一种合成方法，使其能够生产出这些多糖，并包括它们的制药组合物。
• Aqueous dispersion of polytetrafluorethylene and process for its production
  申请人：Asahi Glass Company, Limited

  公开号：EP1731534A1

  公开（公告）日：2006-12-13

  To obtain a high concentration aqueous PTFE dispersion containing PTFE at a concentration of from 60 to 75 mass% by dissolving from 0.001 to 0.1 mass%, based on the mass of PTFE, of a specific carboxylic acid salt such as ammonium laurate in a low concentration aqueous dispersion of polytetrafluoroethylene (PTFE) comprising from 1 to 40 mass% of PTFE fine particles, from 0.0001 to 0.02 mass%, based on the mass of PTFE, of a specific fluorine-containing carboxylic acid type emulsifier (for example, ammonium perfluorooctanoate), and from 1 to 20 mass%, based on the mass of PTFE, of a specific nonionic surfactant, and then concentrating the low concentration aqueous dispersion of PTFE. The present invention provides a process for producing a high concentration aqueous PTFE dispersion containing PTFE at a high concentration by using, as a starting material, a low concentration aqueous dispersion of PTFE containing a fluorine-containing carboxylic acid type emulsifier (PFCA) at a low concentration, and an aqueous PTFE dispersion obtained from the high concentration aqueous PTFE dispersion.

  将 0.001 至 0.1 质量％（以 PTFE 的质量为基准）的特定羧酸盐（如月桂酸铵）溶解在由 1 至 40 质量％的 PTFE 细颗粒、0.0001至0.02质量％的特定含氟羧酸型乳化剂（例如，全氟辛酸铵），以及1至20质量％的特定非离子表面活性剂（基于PTFE的质量），然后浓缩PTFE的低浓度水分散液。本发明提供了一种生产高浓度水性聚四氟乙烯分散液的工艺，其方法是使用含有低浓度含氟羧酸型乳化剂（PFCA）的低浓度聚四氟乙烯水性分散液作为起始原料，以及从高浓度聚四氟乙烯水性分散液中得到的水性聚四氟乙烯分散液。