1-(3-环戊烯-1-基)-3-氟苯 | 369650-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(3-环戊烯-1-基)-3-氟苯
• 英文名称: 1-(cyclopent-3-enyl)-3-fluorobenzene
• 英文别名: (cyclopenta-3-enyl)-3-fluorobenzene；1-(Cyclopent-3-en-1-yl)-3-fluorobenzene；1-cyclopent-3-en-1-yl-3-fluorobenzene
• CAS: 369650-25-9
• 化学式: C₁₁H₁₁F
• 分子量: 162.207
• InChiKey: SWDZRLCCPTWFMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(3-环戊烯-1-基)-3-氟苯 在 sodium periodate 、 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 生成 3-(3-Fluorophenyl)pentanedial
  参考文献：
  名称：

  Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

  摘要：

  The structure-activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate beta-amyloid peptide synthesis via gamma-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficacious in reducing the cortical A beta x-40 levels in FVB mice via a single PO dose, as well as sulfonamide-pyrazoles that exhibit selectivity for inhibition of APP versus Notch processing by gamma-secretase, are highlighted. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.008
• 作为产物：
  描述：

  1-fluoro-3-(hepta-1,6-dien-4-yl)benzene 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 生成 1-(3-环戊烯-1-基)-3-氟苯
  参考文献：
  名称：

  Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

  摘要：

  The structure-activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate beta-amyloid peptide synthesis via gamma-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficacious in reducing the cortical A beta x-40 levels in FVB mice via a single PO dose, as well as sulfonamide-pyrazoles that exhibit selectivity for inhibition of APP versus Notch processing by gamma-secretase, are highlighted. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.008

文献信息

• A rapid and general access to 3-arylpiperidines
  作者：Isabel K Büchner、Peter Metz

  DOI：10.1016/s0040-4039(01)01045-0

  日期：2001.8

  A short and efficient synthetic sequence to produce a wide variety of 3-arylpiperidines from three simple building blocks is described. The key step is a palladium-catalyzed arylation of cyclopentene.

  描述了一种短而有效的合成序列，该序列可从三个简单的结构单元生产出多种3-芳基哌啶。关键步骤是钯催化的环戊烯芳基化。
• Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors
  作者：Danielle L. Aubele、Anh P. Truong、Darren B. Dressen、Gary D. Probst、Simeon Bowers、Matthew N. Mattson、Chris M. Semko、Minghua Sun、Albert W. Garofalo、Andrei W. Konradi、Hing L. Sham、Wes Zmolek、Karina Wong、Erich Goldbach、Kevin P. Quinn、John-Michael Sauer、Elizabeth F. Brigham、William Wallace、Lan Nguyen、Michael P. Bova、Susanna S. Hemphill、Guriqbal Basi

  DOI：10.1016/j.bmcl.2011.08.008

  日期：2011.10

  The structure-activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate beta-amyloid peptide synthesis via gamma-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficacious in reducing the cortical A beta x-40 levels in FVB mice via a single PO dose, as well as sulfonamide-pyrazoles that exhibit selectivity for inhibition of APP versus Notch processing by gamma-secretase, are highlighted. (C) 2011 Elsevier Ltd. All rights reserved.