申请人:The Florida State University Research Foundation, Inc.
公开号:US10982121B2
公开(公告)日:2021-04-20
Disclosed are terpolymer adhesives comprising three different repeating domains: a catechol containing domain, a zwitterionic domain, and a crosslinking domain. In specific examples, the polymer can contain a 3,4-dihydroxy-L-phenylalanine (DOPA) segment which contains a catechol group, a poly(sulfobetaine methacrylate) (polySBMA), and poly(ethylene glycol) dimethacrylate (PEGDMA) for light crosslinking. Alternatively, a photocleavable nitrobenzyloxycarbonyl containing crosslinker can be used. The disclosed polymers can be used as biomedical adhesives, such as to prevent leakage from the sutured intestinal tissue.
所公开的三元共聚物粘合剂包含三个不同的重复结构域:含邻苯二酚结构域、齐聚物结构域和交联结构域。在具体例子中,聚合物可以包含一个含有儿茶酚基团的 3,4-二羟基-L-苯丙氨酸(DOPA)区段、一个聚(磺基甜菜碱甲基丙烯酸酯)(polySBMA)和用于光交联的聚(乙二醇)二甲基丙烯酸酯(PEGDMA)。另外,还可以使用含硝基苯甲酰的光可裂解交联剂。所公开的聚合物可用作生物医学粘合剂,例如防止缝合的肠道组织渗漏。